189490 | Autophagy Inhibitor, 3-MA - CAS 5142-23-4 - Calbiochem

189490
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆H₇N₅ 5142-23-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189490-100MG
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          Glass bottle 100 mg
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          189490-50MG
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              Plastic ampoule 50 mg
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              Description
              OverviewA widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
              Catalogue Number189490
              Brand Family Calbiochem®
              Synonyms3-Methyladenine
              References
              ReferencesCanu, N., et al. 2005. J. Neurochem. 92, 1228.
              Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
              Beugnet, A., et al. 2003. Biochem. J. 372, 555.
              Eskelinen, E.L., et al. 2002. Traffic 3, 878.
              Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
              Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.
              Product Information
              CAS number5142-23-4
              FormWhite to faint yellow powder
              Hill FormulaC₆H₇N₅
              Chemical formulaC₆H₇N₅
              Structure formula ImageStructure formula Image
              Applications
              ApplicationAutophagy Inhibitor, 3-MA, CAS 5142-23-4, is a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis following serum/potassium deprivation.
              Biological Information
              Purity≥95% by HPLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              189490

              References

              Reference overview
              Canu, N., et al. 2005. J. Neurochem. 92, 1228.
              Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
              Beugnet, A., et al. 2003. Biochem. J. 372, 555.
              Eskelinen, E.L., et al. 2002. Traffic 3, 878.
              Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
              Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision14-May-2012 JSW
              Synonyms3-Methyladenine
              DescriptionA widely used cell-permeable autophagic sequestration blocker that effectly protects cerebellar granule cells from apoptosis following serum/potassium deprivation. Although a known class III PI3K inhibitor (IC50 = 4.5 mM in cell-free enzymatic assays), 3-MA exhibits quite distinct pharmacological properties from those of two other PI3K inhibitors, LY 294002 (Cat. Nos. 440202 and 440204) and Wortmannin (Cat. No. 681675)
              FormWhite to faint yellow powder
              Intert gas (Yes/No) Packaged under inert gas
              CAS number5142-23-4
              Chemical formulaC₆H₇N₅
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (10 mg/ml) or H₂O (5 mg/ml). In applications where high working concentrations are necessary (e.g. 10 mM), the use of a pre-made stock solution may result in the introduction of higher than desired solvent (e.g., DMSO) into the experimental systems. In such cases, it is recommended that the solid compound be weighed out at the time of use and reconstituted directly into the solutions used in the experimental system (buffers, media, etc.). Vortexing may be required for complete solubilization in water.
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesCanu, N., et al. 2005. J. Neurochem. 92, 1228.
              Hirosako, K., et al. 2004. Biochem. Biophys. Res. Commun. 316, 845.
              Beugnet, A., et al. 2003. Biochem. J. 372, 555.
              Eskelinen, E.L., et al. 2002. Traffic 3, 878.
              Petiot, A., et al. 2000. J. Biol. Chem. 275, 992.
              Seglen, P.O. and Gordon, P.B., 1982. Proc. Natl. Acad. Sci. USA 79, 1889.