189406 Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

189406
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₂F₂N₆O₃S • CH₃CN 443797-96-4
      Description
      OverviewA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112 - 514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
      Catalogue Number189406
      Brand Family Calbiochem®
      Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, JNJ-7706621, Aurora Kinase Inhibitor I
      References
      ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
      Lin R., et al. 2005. J. Med. Chem. 48, 4208.
      Product Information
      CAS number443797-96-4
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
      Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetAurora Kinase/Cdk
      Primary Target IC<sub>50</sub>11 and 15 nM for Aurora-A, Aurora-B, respectively; 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      189406

      References

      Reference overview
      Emanuel, S., et al. 2005. Cancer Res. 65, 9038.
      Lin R., et al. 2005. J. Med. Chem. 48, 4208.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2008 RFH
      Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, JNJ-7706621, Aurora Kinase Inhibitor I
      DescriptionA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112-514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number443797-96-4
      Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (15 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
      Lin R., et al. 2005. J. Med. Chem. 48, 4208.