189291 | Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem

189291
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      [(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2 134523-03-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      189291-100MG
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          Glass bottle 100 mg
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          Description
          OverviewA cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.
          Catalogue Number189291
          Brand Family Calbiochem®
          Synonyms(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,
          References
          ReferencesChen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
          Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
          Law, M.R., et al. 2003. BMJ 326, 1423.
          Youssef, S., et al. 2002. Nature 420, 78.
          Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
          Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
          Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
          Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
          Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.
          Product Information
          CAS number134523-03-8
          FormWhite powder
          Hill Formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
          Chemical formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Applications
          ApplicationAtorvastatin, Calcium Salt, CAS 134523-03-8, is a cell-permeable, highly potent, and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver).
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          189291

          References

          Reference overview
          Chen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
          Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
          Law, M.R., et al. 2003. BMJ 326, 1423.
          Youssef, S., et al. 2002. Nature 420, 78.
          Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
          Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
          Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
          Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
          Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-May-2012 JSW
          Synonyms(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,
          DescriptionA cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.
          FormWhite powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number134523-03-8
          Chemical formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml; clear, colorless solution) or Methanol (10 mg/ml; clear, colorless solution) or Ethanol (2 mg/ml; clear, colorless solution). Not soluble in H₂O.
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesChen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
          Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
          Law, M.R., et al. 2003. BMJ 326, 1423.
          Youssef, S., et al. 2002. Nature 420, 78.
          Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
          Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
          Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
          Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
          Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.