182516 Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem

182516
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇H₁₆BrNO₃S
      Description
      OverviewA cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 µM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 µM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No. 182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control.
      Catalogue Number182516
      Brand Family Calbiochem®
      Synonyms2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869, Actin Assembly Inhibitor XIV
      References
      ReferencesNolen, B.J., et al. 2009. Nature 460, 1031.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₇H₁₆BrNO₃S
      Chemical formulaC₁₇H₁₆BrNO₃S
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Arp2/3 Complex Inhibitor II, CK-869 - Calbiochem Certificates of Analysis

      TitleLot Number
      182516

      References

      Reference overview
      Nolen, B.J., et al. 2009. Nature 460, 1031.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-May-2010 RFH
      Synonyms2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869, Actin Assembly Inhibitor XIV
      DescriptionA cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 µM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 µM). Structural studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₆BrNO₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNolen, B.J., et al. 2009. Nature 460, 1031.