616399 Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem

616399
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #
      9087-70-1

      Pricing & Availability

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      616399-100KU
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          Glass bottle 100 ku
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          616399-500KU
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              Plastic ampoule 500 ku
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              Description
              Overview

              This product has been discontinued.



              Competitive reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful in protein purification and for extending the life of cells in culture by preventing proteolytic damage.

              Note: 1 KU = 1000 K.I.U.
              Catalogue Number616399
              Brand Family Calbiochem®
              SynonymsKallikrein Inactivator
              References
              ReferencesAzougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
              Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
              Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
              Product Information
              CAS number9087-70-1
              Activity≥6500 KIU/ml
              Unit of DefinitionOne Kallikrein Inhibitory Unit (KIU) is identical to the quantity of protease inhibitor that has the ability to inhibit two kallikrein units by 50% under optimal conditions
              ATP CompetitiveN
              FormLiquid
              FormulationIn isotonic NaCl, aseptically filled.
              PI10.5
              ReversibleY
              Applications
              Biological Information
              Primary Targetchymotrypsin
              Primary Target IC<sub>50</sub>Kd = 5 x 10-14 M, 2.3 x 10-10 M, 1 x 10-7 M against trypsin, plasmin, and kallikrein, respectively
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSYN5080000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Aprotinin, Bovine Lung, Solution - CAS 9087-70-1 - Calbiochem Certificates of Analysis

              TitleLot Number
              616399

              References

              Reference overview
              Azougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
              Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
              Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision13-May-2010 JSW
              SynonymsKallikrein Inactivator
              DescriptionCompetitive reversible inhibitor of proteolytic and esterolytic activity. A relatively heat- and acid-stable serine protease inhibitor. Forms a tight complex, blocking the active site of the enzyme. Effective at concentrations equimolar with protease. Inhibits several proteases, including coagulation factors in the prephase of blood clotting, tissue and leukocytic proteinases, chymotrypsin, trypsin (Kd = 5 x 10-14 M), plasmin (Kd = 2.3 x 10-10 M), and kallikrein (Kd = 1 x 10-7 M). Proteases not inhibited by aprotinin include Factor Xa, thrombin, pepsin, papain, and carboxypeptidases A and B. Useful in protein purification and for extending the life of cells in culture by preventing proteolytic damage.
              FormLiquid
              FormulationIn isotonic NaCl, aseptically filled.
              CAS number9087-70-1
              RTECSYN5080000
              Activity≥6500 KIU/ml
              Unit definitionOne Kallikrein Inhibitory Unit (KIU) is identical to the quantity of protease inhibitor that has the ability to inhibit two kallikrein units by 50% under optimal conditions
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Toxicity Standard Handling
              Merck USA index14, 757
              ReferencesAzougagh Oualane, F., et al. 1992. Thromb. Res. 68, 185.
              Anderson, L.O., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2979.
              Kruithof, W.L., et al. 1986. Biochem. J. 226, 631.