178486 Apoptosis Inducer Set I - Calbiochem

178486
  
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      Overview

      Replacement Information

      Key Specifications Table

      Description
      OverviewThis set contains five ready-to-use chemical reagents that induce apoptosis through different mechanisms. The set contains DMSO solutions of Actinomycin D, Streptomyces sp. (10 mM; Cat. No. 114666), Camptothecin, Camptotheca acuminata (2 mM; Cat. No. 208925), Cycloheximide (100 mM; Cat. No. 239764), Dexamethasone (10 mM; Cat. No. 265005), and Etoposide (100 mM; Cat. No. 341205). Recommended dilution for use: 1:1000. Supplied with a data sheet.
      Catalogue Number178486
      Brand Family Calbiochem®
      Application Data
      References
      ReferencesSuzuki, A., and Keto, M. 1996. Exp. Cell. Res. 227, 154.
      Martin, S.J., et al. 1995. J. Exp. Med. 182, 1545.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Fearnhead, H.O., et al. 1994. Biochem. Pharmacol. 48, 1073.
      Onishi, Y., et al. 1993. Biochem. Biophys. Acta 1175, 147.
      Product Information
      FormLiquid
      FormulationAll components are supplied in DMSO.
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 26/27/28-36/37/38-43-45-46-40-61-62-63

      Very toxic by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      May cause cancer.
      May cause heritable genetic damage.
      Limited evidence of a carcinogenic effect.
      May cause harm to the unborn child.
      Possible risk of impaired fertility.
      Possible risk of harm to the unborn child.
      S PhraseS: 26-36/37/39-45-53-3/7/9-23

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Keep container tightly closed, in a cool well ventilated place.
      Do not breathe fumes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Apoptosis Inducer Set I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Apoptosis Inducer Set I - Calbiochem Certificates of Analysis

      TitleLot Number
      178486

      References

      Reference overview
      Suzuki, A., and Keto, M. 1996. Exp. Cell. Res. 227, 154.
      Martin, S.J., et al. 1995. J. Exp. Med. 182, 1545.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Fearnhead, H.O., et al. 1994. Biochem. Pharmacol. 48, 1073.
      Onishi, Y., et al. 1993. Biochem. Biophys. Acta 1175, 147.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2008 RFH
      Application Data
      DescriptionThe set contains 5 ready-to-use chemical reagents that induce apoptosis through different mechanisms. Actinomycin D, an anti-neoplastic antibiotic, inhibits RNA synthesis. Camptothecin and etoposide are inhibitors of nuclear topoisomerase. Cycloheximide, an active antibiotic against many yeast and fungi, inhibits protein synthesis. Dexamethasone, an active and highly stable glucocorticoid, probably induces apoptosis by binding and activating the intracellular glucocorticoid receptor. Supplied with a data sheet.
      FormLiquid
      FormulationAll components are supplied in DMSO.
      Recommended reaction conditionsA 1:1000 is recommended for inducing apoptosis in cell culture with these apoptosis-inducing reagents. The optimal dosie may vary for different cell types and culture conditions. Please consult published literature to determine the optimal concentration and incubation time for specific cell types.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Multiple Toxicity Values, refer to MSDS
      ReferencesSuzuki, A., and Keto, M. 1996. Exp. Cell. Res. 227, 154.
      Martin, S.J., et al. 1995. J. Exp. Med. 182, 1545.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Fearnhead, H.O., et al. 1994. Biochem. Pharmacol. 48, 1073.
      Onishi, Y., et al. 1993. Biochem. Biophys. Acta 1175, 147.