178497 Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

178497
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₃H₂₄F₆N₃O₃ 1054543-47-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178497-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 hours drug treatment (1 µM).
          Catalogue Number178497
          Brand Family Calbiochem®
          SynonymsN-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole, Hsp70 Inhibitor III
          References
          ReferencesCho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
          Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
          Product Information
          CAS number1054543-47-3
          FormWhite solid
          Hill FormulaC₃₃H₂₄F₆N₃O₃
          Chemical formulaC₃₃H₂₄F₆N₃O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          178497

          References

          Reference overview
          Cho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
          Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2013 JSW
          SynonymsN-(4-Carboxamidobenzyl)-2-(3,5-bis-trifluoromethyl)-4,5-bis-(4-methoxyphenyl)-imidazole, Hsp70 Inhibitor III
          DescriptionA cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (Kd = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC50 = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 h drug treatment (1 µM). Shown to suppress ubiquitination of mutant CFTR and promote membrane trafficking, and restore chloride channel activity.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1054543-47-3
          Chemical formulaC₃₃H₂₄F₆N₃O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml) or Ethanol (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesCho, H.J., et al. 2012. J. Am. Chem. Soc. 133, 20267.
          Williams, D.R., et al. 2008. Angew. Chem. Int. Ed. 47, 7466.