OP53 Anti-c-Fos (Ab-3) Mouse mAb (CS93.1.18)

OP53
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H, M M Monoclonal Antibody

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      OP53-100UG
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          Glass bottle 100 μg
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          Description
          OverviewRecognizes the ~50-62 kDa c-Fos protein in serum-stimulated NIH3T3 cells and A431 cells. Also recognizes v-fos.
          Catalogue NumberOP53
          Brand Family Calbiochem®
          References
          ReferencesRouscher III, F.J., et al. 1988. Science 240, 1010.
          Sassone-Corsi, P., et al. 1988. Cell 54, 553.
          Verma, I.M., and Graham, W.R.,1987. Adv. Cancer Res. 49, 29.
          Verma, I.M., and Sassone-Corsi, P., 1987. Cell 52, 513).
          Muller, R., 1986. Biochim. Biophys. Acta 823, 207.
          Verma, I.M., 1986. Trends Genet. 2, 93.
          Greenberg, M., and Ziff, E., 1984. Nature, London 311, 433.
          Product Information
          FormLiquid
          FormulationIn 0.05 M sodium phosphate buffer, 50% glycerol.
          Negative controlGrowth-arrested cells
          Positive controlSerum-stimulated NIH 3T3 cells or A431 cells
          PreservativeNone
          Applications
          Key Applications Immunoblotting (Western Blotting)
          Paraffin Sections
          Application NotesImmunoblotting (1-5 µg/ml)
          Paraffin Sections (1-10 µg/ml; pepsin pre-treatment required)
          Application CommentsThis antibody will react with both cellular and viral forms of Fos. The immunogen c-Fos (Peptide-2), Cat. No. PP10, is also available for competition studies. Antibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogena synthetic peptide (SGFNADYEASSSRC) (Cat. No. PP10) corresponding to amino acids 4-17 of human c-Fos
          ImmunogenHuman
          CloneCS93.1.18
          HostMouse
          IsotypeIgG₁
          Species Reactivity
          • Human
          • Mouse
          Antibody TypeMonoclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Anti-c-Fos (Ab-3) Mouse mAb (CS93.1.18) SDS

          Title

          Safety Data Sheet (SDS) 

          Anti-c-Fos (Ab-3) Mouse mAb (CS93.1.18) Certificates of Analysis

          TitleLot Number
          OP53

          References

          Reference overview
          Rouscher III, F.J., et al. 1988. Science 240, 1010.
          Sassone-Corsi, P., et al. 1988. Cell 54, 553.
          Verma, I.M., and Graham, W.R.,1987. Adv. Cancer Res. 49, 29.
          Verma, I.M., and Sassone-Corsi, P., 1987. Cell 52, 513).
          Muller, R., 1986. Biochim. Biophys. Acta 823, 207.
          Verma, I.M., 1986. Trends Genet. 2, 93.
          Greenberg, M., and Ziff, E., 1984. Nature, London 311, 433.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          ApplicationImmunoblotting (1-5 µg/ml)
          Paraffin Sections (1-10 µg/ml; pepsin pre-treatment required)
          DescriptionPurified mouse monoclonal antibody generated by immunizing BALB/c mice with the specified immunogen and fusing splenocytes with SP2/0-AG14 plasmacytoma cells. Recognizes the ~50-62 kDa Fos protein.
          BackgroundThe proto-oncogene fos has been implicated in cell growth, differentiation and development. c-Fos is induced by a large number of stimuli including from mitogens, differentiation-specific agents and pharmacological agents. Induction of the 62 kDa Fos protein is rapid but transient. The Fos protein is associated with a 39 kDa protein which has been identified as the protein product of the Jun proto-oncogene (c-jun). The Fos/Jun protein complex binds specifically to a sequence element in DNA referred to as the AP-1 binding site.
          HostMouse
          Immunogen speciesHuman
          Immunogena synthetic peptide (SGFNADYEASSSRC) (Cat. No. PP10) corresponding to amino acids 4-17 of human c-Fos
          CloneCS93.1.18
          IsotypeIgG₁
          Specieshuman, mouse
          Positive controlSerum-stimulated NIH 3T3 cells or A431 cells
          Negative controlGrowth-arrested cells
          FormLiquid
          FormulationIn 0.05 M sodium phosphate buffer, 50% glycerol.
          Concentration Label Please refer to vial label for lot-specific concentration
          PreservativeNone
          CommentsThis antibody will react with both cellular and viral forms of Fos. The immunogen c-Fos (Peptide-2), Cat. No. PP10, is also available for competition studies. Antibody should be titrated for optimal results in individual systems.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesRouscher III, F.J., et al. 1988. Science 240, 1010.
          Sassone-Corsi, P., et al. 1988. Cell 54, 553.
          Verma, I.M., and Graham, W.R.,1987. Adv. Cancer Res. 49, 29.
          Verma, I.M., and Sassone-Corsi, P., 1987. Cell 52, 513).
          Muller, R., 1986. Biochim. Biophys. Acta 823, 207.
          Verma, I.M., 1986. Trends Genet. 2, 93.
          Greenberg, M., and Ziff, E., 1984. Nature, London 311, 433.