MABT20 Anti-OL-protocadherin Antibody, clone 5G10

MABT20
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M WB, ICC, IHC R Purified Monoclonal Antibody
      Description
      Catalogue NumberMABT20
      DescriptionAnti-OL-protocadherin Antibody, clone 5G10
      Alternate Names
      • protocadherin 10
      • ortholog of OL-pcdh
      Background InformationOL-protocadherin (OL-pc, protocadherin 10) is a transmembrane protein and a member of the cadherin superfamily, which is characterized by its members’ abilities to undergo interactions that are homophilic in nature via their extracellular domain. Several protocadherins have been observed within the nervous system, and a few have been shown to localize at synapses. With OL-pc, the homophilic binding has been shown to stimulate cell aggregation when the protein is introduced into cadherin-deficient cells. Although the function of OL-protocadherin has yet to be elucidated, studies have shown OL-pc to be necessary to axonal normal projection through the ventral telencephalon, where OL-pc shows highest expression at the striatal region.
      References
      Product Information
      FormatPurified
      Control
      • Mouse E13-E14 brain tissue lysate
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-OL-protocadherin Antibody, clone 5G10 is an antibody against OL-protocadherin for use in WB, IC, IH.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunofluorescence Analysis: The antibody has been shown to detect OL-protocadherin in IF. (Nakao, 2008).

      Immunohistochemistry Analysis: The antibody has been shown to detect OL-protocadherin in IH. (Aoki, 2003).
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the cytoplasmic domain of mouse OL-protocadherin.
      EpitopeCytoplasmic domain
      Clone5G10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityThe antibody recognizes the cytoplasmic domain of OL-protocadherin.
      IsotypeIgG2aκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Pcdh10
      • OL-PCDH
      • Pcadh10
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummarySEQUENCE SIMILARITIES: Contains 6 cadherin domains. (Spearmint SPM002126)
      Molecular Weight ~ 130 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse E13-E14 brain tissue lysate.

      Western Blot Analysis: 1 µg/mL of the antibody detected OL-protocadherin in 10 µg of mouse E13-E14 brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-OL-protocadherin Antibody, clone 5G10 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-OL-protocadherin Antibody, clone 5G10 Certificates of Analysis

      TitleLot Number
      Anti-OL-protocadherin, clone 5G10 - 23940702394070
      Anti-OL-protocadherin, clone 5G10 - 20069762006976
      Anti-OL-protocadherin, clone 5G10 - NG1940973NG1940973
      Anti-OL-protocadherin, clone 5G10 - NRG1759424NRG1759424
      Anti-OL-protocadherin, clone 5G10 -26078612607861
      Anti-OL-protocadherin, clone 5G10 -27900872790087
      Anti-OL-protocadherin, clone 5G10 -28444482844448
      Anti-OL-protocadherin, clone 5G10 Monoclonal Antibody3076543
      Anti-OL-protocadherin, clone 5G10 Monoclonal Antibody2970630
      Anti-OL-protocadherin, clone 5G10 Monoclonal Antibody3003754

      References

      Reference overviewPub Med ID
      Clustered fine compartmentalization of the mouse embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration.
      Fujita, H; Morita, N; Furuichi, T; Sugihara, I
      The Journal of neuroscience : the official journal of the Society for Neuroscience  32  15688-703  2012

      Show Abstract
      23136409 23136409