437695 Anti-Lipoic Acid Rabbit pAb

437695
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      A Broad Range Of Species Rb Polyclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      437695-100UL
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
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          Will advise
          Contact Customer Service
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          Plastic ampoule 100 ul
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          Description
          OverviewRecognizes native lipoic acid. Does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
          Catalogue Number437695
          Brand Family Calbiochem®
          SynonymsAnti-LA
          References
          ReferencesSasaki, M., et al. 2000. J. Autoimmun. 15, 51.
          Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
          Patrick. L. 2000. Altern. Med. Rev. 5, 290.
          Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
          Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.
          Product Information
          FormLiquid
          Formulationserum diluted in buffer, 50% glycerol, pH 7.5.
          PreservativeNone
          Applications
          Key Applications Paraffin Sections
          Enzyme-Linked Immunosorbent Assay
          Frozen Sections
          Immunoblotting (Western Blotting)
          Application NotesELISA (1:500-1:1000)
          Frozen Sections (1:50-1:500)
          Immunoblotting (1:1000-1:10,000)
          Paraffin Sections (1:50-1:500)
          Application CommentsDoes not bind lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. Useful for assessing whether protein-bound lipoic acids have undergone certain forms of oxidative modification. The presence of protein-bound lipoic acid can be used as a marker for mitochondria. Variables associated with assay conditions will dictate the optimal working dilution.
          Biological Information
          Immunogenlipoic acid conjugated to KLH
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • A Broad Range Of Species
          Antibody TypePolyclonal Antibody
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          437695

          References

          Reference overview
          Sasaki, M., et al. 2000. J. Autoimmun. 15, 51.
          Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
          Patrick. L. 2000. Altern. Med. Rev. 5, 290.
          Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
          Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-August-2007 RFH
          SynonymsAnti-LA
          ApplicationELISA (1:500-1:1000)
          Frozen Sections (1:50-1:500)
          Immunoblotting (1:1000-1:10,000)
          Paraffin Sections (1:50-1:500)
          DescriptionRabbit polyclonal antibody supplied as diluted serum. Recognizes native lipoic acid and lipoic acid covalently attached to proteins.
          BackgroundLipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, α-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.
          HostRabbit
          Immunogenlipoic acid conjugated to KLH
          IsotypeIgG
          Speciesa broad range of species
          FormLiquid
          Formulationserum diluted in buffer, 50% glycerol, pH 7.5.
          PreservativeNone
          CommentsDoes not bind lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. Useful for assessing whether protein-bound lipoic acids have undergone certain forms of oxidative modification. The presence of protein-bound lipoic acid can be used as a marker for mitochondria. Variables associated with assay conditions will dictate the optimal working dilution.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesSasaki, M., et al. 2000. J. Autoimmun. 15, 51.
          Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
          Patrick. L. 2000. Altern. Med. Rev. 5, 290.
          Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
          Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.