423500 | Anti-Klotho Rabbit pAb

423500
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      M Rb Polyclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      423500-50UG
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      Discontinued
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          Glass bottle 50 μg
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          Description
          OverviewRecognizes the ~100 kDa Klotho protein.
          Catalogue Number423500
          Brand Family Calbiochem®
          SynonymsAnti-KL
          References
          ReferencesKuro-o, M., et al. 1997. Nature 390, 45.
          Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.
          Product Information
          FormLiquid
          FormulationIn PBS, 0.1% BSA, pH 7.5.
          PreservativeNone
          Applications
          Key Applications Enzyme-Linked Immunosorbent Assay
          Immunoblotting (Western Blotting)
          Application NotesELISA (1:10,000-1:100,000)
          Immunoblotting (1-10 µg/ml, chemiluminescence)
          Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
          Biological Information
          Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of murine Klotho
          ImmunogenMouse
          HostRabbit
          IsotypeIgG
          Species Reactivity
          • Mouse
          Antibody TypePolyclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          423500

          References

          Reference overview
          Kuro-o, M., et al. 1997. Nature 390, 45.
          Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-October-2009 RFH
          SynonymsAnti-KL
          ApplicationELISA (1:10,000-1:100,000)
          Immunoblotting (1-10 µg/ml, chemiluminescence)
          DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~100 kDa Klotho protein.
          BackgroundInactivation mutation of the recently discovered klotho gene in mice causes a syndrome resembling aging. Homozygous mutant klotho (kl/kl) mice exhibit premature aging phenotypes such as osteoporosis, age related skin changes, ectopic calcification, atrophy of genital organs and thymus, atherosclerosis, emphysema, ataxia, and short life span. The kl gene encodes a membrane protein whose extracellular domain carries homology to β-glucosidases. There also exists a splice variant of kl mRNA that encodes a putative secreted protein in both human and mouse. kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway.
          HostRabbit
          Immunogen speciesMouse
          Immunogena synthetic peptide corresponding to a 17-amino acid sequence near the C-terminus of murine Klotho
          IsotypeIgG
          Speciesmouse
          FormLiquid
          FormulationIn PBS, 0.1% BSA, pH 7.5.
          Concentration Label Please refer to vial label for lot-specific concentration
          PreservativeNone
          CommentsVariables associated with assay conditions will dictate the optimal working dilution.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesKuro-o, M., et al. 1997. Nature 390, 45.
          Martin, G.M. and Mian, I.S. 1997. Nature 390, 18.