204869 Anti-Complement 3 Goat pAb

204869
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      Bab, Gp, Ht, Eq, H, M, Rb, R Gt Polyclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      204869-1ML
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          Plastic ampoule 1 ml
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          Description
          OverviewMonospecific for C3 complement component. May also recognize C3 fragments, C3a, C3b, and C3c.
          Catalogue Number204869
          Brand Family Calbiochem®
          References
          ReferencesInal, J.M., et al. 2002. J. Immunol. 168, 5213.
          Williams, B.J., et al. 2001. Infect. Immun. 69, 695.
          Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.
          Product Information
          FormLiquid
          FormulationSerum diluted in 500 mM NaCl, 50 mM Tris-HCl, pH 7.5.
          Positive controlPurified C3 protein (Cat. No. 204885)
          Preservative≤0.1% sodium azide
          Applications
          Application ReferencesImmunoblotting Inal, J.M., et al. 2002. J. Immunol. 168, 5213. Williams, B.J., et al. 2001. Infect. Immun. 69, 695. Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128. Flow Cytometry Williams, B.J., et al. 2001. Infect. Immun. 69, 695. Immunocytochemistry Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.
          Key Applications Immunoelectrophoresis
          Flow Cytometry
          Immunoblotting (Western Blotting)
          Immunocytochemistry
          Application NotesFlow Cytometry (see application references)
          Immunoblotting (see application references)
          Immunocytochemistry (see application references)
          Immunoelectrophoresis (use undiluted)
          Application CommentsMonospecific to human C3 complement component. This antibody has also been reported to recognize the C3 fragments, C3a, C3b, and C3c. Antibody should be titrated for optimal results in individual systems.
          Biological Information
          Immunogenpurified, human C3 complement component
          ImmunogenHuman
          HostGoat
          IsotypeIgG
          Species Reactivity
          • Baboon
          • Guinea Pig
          • Hamster
          • Horse
          • Human
          • Mouse
          • Rabbit
          • Rat
          Antibody TypePolyclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          204869

          References

          Reference overview
          Inal, J.M., et al. 2002. J. Immunol. 168, 5213.
          Williams, B.J., et al. 2001. Infect. Immun. 69, 695.
          Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.

          Citations

          Title
        • Jameel M. Inal and Jurg A. Schifferli. (2002) Complement C2 Receptor Inhibitor Trispanning and the β-Chain of C4 Share a Binding Site for Complement C21. Journal of Immunology 168, 5213-5221.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-July-2007 RFH
          ApplicationFlow Cytometry (see application references)
          Immunoblotting (see application references)
          Immunocytochemistry (see application references)
          Immunoelectrophoresis (use undiluted)
          DescriptionGoat polyclonal antibody supplied as defibrinated, delipidized, and adsorbed (as needed) serum. Recognizes the C3 complement component.
          BackgroundThe complement system provides innate defense against microbial infection and is a "complement" to antibody mediated immunity. The complement system consists of thirty five interacting plasma and membrane associated proteins which contribute to host-defense and initiate and amplify inflammation, even in the preimmune state where specific antibodies and lymphocytes are not available. In addition to the complement components themselves, this system also contains several soluble factors that prevent spontaneous complement activation from occurring in solution, as well as, several regulatory membrane associated proteins that protect host cells from accidental complement attack. Cleavage of the C3 component by either the classical pathway or the alternative pathway releases C3a and C3b. C3a appears to be important in many inflammatory responses while the C3b fragment covalently binds to the cell or bacterial surface and plays a role in opsonisation. Binding of C3b to the C4b component of the C3 convertase, results in C5 convertase (C4b3b2a) formation.
          HostGoat
          Immunogen speciesHuman
          Immunogenpurified, human C3 complement component
          IsotypeIgG
          Speciesbaboon, not bovine, not canine, not chicken, not feline, guinea pig, hamster, horse, human, mouse, rabbit, rat, not sheep
          Positive controlPurified C3 protein (Cat. No. 204885)
          FormLiquid
          FormulationSerum diluted in 500 mM NaCl, 50 mM Tris-HCl, pH 7.5.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsMonospecific to human C3 complement component. This antibody has also been reported to recognize the C3 fragments, C3a, C3b, and C3c. Antibody should be titrated for optimal results in individual systems.
          Storage -20°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Standard Handling
          ReferencesInal, J.M., et al. 2002. J. Immunol. 168, 5213.
          Williams, B.J., et al. 2001. Infect. Immun. 69, 695.
          Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.
          Citation
        • Jameel M. Inal and Jurg A. Schifferli. (2002) Complement C2 Receptor Inhibitor Trispanning and the β-Chain of C4 Share a Binding Site for Complement C21. Journal of Immunology 168, 5213-5221.
        • Application referencesImmunoblotting Inal, J.M., et al. 2002. J. Immunol. 168, 5213. Williams, B.J., et al. 2001. Infect. Immun. 69, 695. Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128. Flow Cytometry Williams, B.J., et al. 2001. Infect. Immun. 69, 695. Immunocytochemistry Hindmarsh, E.J., et al. 1998. J. Immunol. 160, 6128.