217640 | Anti-CD11a Mouse mAb (38)

217640
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      H M Monoclonal Antibody

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      217640-100UG
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          Plastic ampoule 100 μg
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          Description
          OverviewRecognizes the ~180 kDa I domain of the αL integrin subunit in Molt-4 human tumor cells.
          Catalogue Number217640
          Brand Family Calbiochem®
          SynonymsAnti-αL Integrin, Anti-LFA-1
          References
          ReferencesHolness, C.L., et al. 1995. J. Biol. Chem. 270, 877.
          Landis, R.C., et al. 1994. J. Cell. Biol. 126, 529.
          Dransfield, I., and Hogg, N. 1989. EMBO J. 8, 3759.
          Product Information
          FormLiquid
          FormulationIn 150 mM NaCl, 100 mM KCl, 50 mM sodium phosphate, pH 7.5.
          Negative controlNalm-6 cells
          Positive controlMolt-4 cells
          Preservative≤0.1% sodium azide
          Applications
          Key Applications Immunoprecipitation
          Cell Inhibition Assays
          Flow Cytometry
          Frozen Sections
          Application NotesCell Inhibition Assays (1-5 µg/ml, see comments)
          Flow Cytometry (5 µg/ml)
          Frozen Sections (see comments)
          Immunoprecipitation (see comments)
          Application CommentsAlso blocks binding of ICAM-1 and ICAM-3 to LFA-1. FACS was performed on 5x105 cultured Molt-4 human tumor cells using anti-CD11a antibody at 5 µg/ml and FITC-conjugated goat anti-mouse IgG. Variables associated with assay conditions will dictate the proper working dilution.
          Biological Information
          Immunogenhuman monocytes
          ImmunogenHuman
          Clone38
          HostMouse
          IsotypeIgG2a
          Species Reactivity
          • Human
          Antibody TypeMonoclonal Antibody
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          217640

          References

          Reference overview
          Holness, C.L., et al. 1995. J. Biol. Chem. 270, 877.
          Landis, R.C., et al. 1994. J. Cell. Biol. 126, 529.
          Dransfield, I., and Hogg, N. 1989. EMBO J. 8, 3759.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-July-2007 RFH
          SynonymsAnti-αL Integrin, Anti-LFA-1
          ApplicationCell Inhibition Assays (1-5 µg/ml, see comments)
          Flow Cytometry (5 µg/ml)
          Frozen Sections (see comments)
          Immunoprecipitation (see comments)
          DescriptionProtein A purified mouse monoclonal antibody. Recognizes the I domain of the ~180 kDa integrin α L subunit (CD11a).
          BackgroundCD11a (αL integrin) complexes with CD18 (β2 integrin) to form the LFA-1 heterodimer adhesion molecule which binds to three ICAM's 1,2, and 3, also designated CD54, CD102, and CD50, respectively. LFA-1 is expressed on lymphocytes, monocytes, and neutrophils and plays a role in cell-cell adhesion.
          HostMouse
          Immunogen speciesHuman
          Immunogenhuman monocytes
          Clone38
          IsotypeIgG2a
          Specieshuman
          Positive controlMolt-4 cells
          Negative controlNalm-6 cells
          FormLiquid
          FormulationIn 150 mM NaCl, 100 mM KCl, 50 mM sodium phosphate, pH 7.5.
          Concentration Label Please refer to vial label for lot-specific concentration
          Preservative≤0.1% sodium azide
          CommentsAlso blocks binding of ICAM-1 and ICAM-3 to LFA-1. FACS was performed on 5x105 cultured Molt-4 human tumor cells using anti-CD11a antibody at 5 µg/ml and FITC-conjugated goat anti-mouse IgG. Variables associated with assay conditions will dictate the proper working dilution.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Toxicity Standard Handling
          ReferencesHolness, C.L., et al. 1995. J. Biol. Chem. 270, 877.
          Landis, R.C., et al. 1994. J. Cell. Biol. 126, 529.
          Dransfield, I., and Hogg, N. 1989. EMBO J. 8, 3759.