MABC266 Anti-Beclin-2 Antibody, clone 4H7.1

MABC266
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, ICC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABC266
      DescriptionAnti-Beclin-2 Antibody, clone 4H7.1
      Alternate Names
      • Beclin-2
      Background InformationThe protein Beclin-2 is encoded by the gene BECN1P1/BECN2 and is involved in two important lysosomal degradation pathways in the brain and other tissues. Beclin-2 acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components and Bcl-2. Beclin-2 is expressed in fetal and adult brain as well as other tissues. Beclin-2 is localized in the cytoplasm. Beclin-2 knockout mice have decreased embryonic viability, and heterozygous knockout mice have defective autophagy, increased levels of brain cannabinoid 1 receptor, elevated food intake, and obesity and insulin resistance. Thus because of its many cellular influences research into Beclin-2 regulation and function is ongoing.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Applications
      ApplicationAnti-Beclin-2 Antibody, clone 4H7.1 is an antibody against Beclin-2 for use in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:250 dilution from a representative lot detected Beclin-2 in A431 cells without and with serum starvation (Note: Increased punctate staining is associated with increased levels of autophagy under serum starved conditions).
      Biological Information
      ImmunogenRecombinant protein corresponding to the Coiled coil domain of human Beclin-2.
      EpitopeCoiled coil domain
      Clone4H7.1
      Concentration0.5 mg/mL
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • BECN1P1
      • BECN2
      Purification MethodPurified by Ion-Exchange Chromatography
      UniProt Number
      Molecular Weight~48 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human fetal brain tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected Beclin-2 in 10 µg of human fetal brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications