126855 Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem

126855
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄H₁₂NNaO₇P₂ • 3H₂O 121268-17-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      126855-100MG
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          Plastic ampoule 100 mg
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          Description
          OverviewAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
          Catalogue Number126855
          Brand Family Calbiochem®
          SynonymsAlendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
          References
          ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
          Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
          Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
          Smith, R., et al. 1971. Lancet 1, 945.
          Fleisch, H., et al. 1969. Nature 223, 211.
          Product Information
          CAS number121268-17-5
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₄H₁₂NNaO₇P₂ • 3H₂O
          Chemical formulaC₄H₁₂NNaO₇P₂ • 3H₂O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetFarnesyl diphosphate synthase
          Primary Target IC<sub>50</sub>460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells
          Purity≥98% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSSZ6523500
          Safety Information
          R PhraseR: 22;

          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          126855

          References

          Reference overview
          Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
          Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
          Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
          Smith, R., et al. 1971. Lancet 1, 945.
          Fleisch, H., et al. 1969. Nature 223, 211.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-April-2008 RFH
          SynonymsAlendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
          DescriptionAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC50 = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC50 = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC50 = 40-70 µM).
          FormWhite solid
          CAS number121268-17-5
          RTECSSZ6523500
          Chemical formulaC₄H₁₂NNaO₇P₂ • 3H₂O
          Structure formulaStructure formula
          Purity≥98% by titration
          SolubilityH₂O (10 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 229
          ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
          Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
          Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
          Smith, R., et al. 1971. Lancet 1, 945.
          Fleisch, H., et al. 1969. Nature 223, 211.