124020 Akt Inhibitor X - CAS 925681-41-0 - Calbiochem

124020
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₅ClN₂O • HCl 925681-41-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      124020-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 µM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. Also available as a 20 mM solution in H2O(Cat. No. 124039).
          Catalogue Number124020
          Brand Family Calbiochem®
          Synonyms10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP
          References
          ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
          Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
          Product Information
          CAS number925681-41-0
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₀H₂₅ClN₂O • HCl
          Chemical formulaC₂₀H₂₅ClN₂O • HCl
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationAkt Inhibitor X, CAS 925681-41-0, is a cell-permeable, reversible & selective inhibitor of Akt phosphorylation and its in vitro kinase activity. Has minimal effect on PI 3-K, PDK1, or SGK1.
          Biological Information
          Primary TargetAkt
          Primary Target IC<sub>50</sub><5 µM against Akt ; 2-5 µM against growth of Rh (rhabdomyosarcoma) cell lines
          Secondary targetRn cell lines (IC₅₀ = 2-5 µM)
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          124020

          References

          Reference overview
          Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
          Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision14-September-2010 JSW
          Synonyms10-(4ʹ-(N-diethylamino)butyl)-2-chlorophenoxazine, HCl, 10-NCP
          DescriptionA cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition < 5 µM) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 μM), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2 (Cat. No. 124018), the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number925681-41-0
          Chemical formulaC₂₀H₂₅ClN₂O • HCl
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesTsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA in press.
          Thimmaiah, K.N., et al. 2005. J. Biol. Chem. 280, 31924.