124014 | Akt Inhibitor VII, TAT-Akt-in - Calbiochem

124014
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₅₂H₂₃₉N₅₅O₃₆

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      124014-2MG
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          Plastic ampoule 2 mg
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          Description
          OverviewA cell-permeable and reversible version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT that displays antitumor properties. Inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells, and tumor growth in syngeneic C57BL/6 mice.
          Catalogue Number124014
          Brand Family Calbiochem®
          SynonymsH-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1₁₀₋₂₄
          References
          ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          FormulationSupplied as an trifluoroacetate salt.
          Hill FormulaC₁₅₂H₂₃₉N₅₅O₃₆
          Chemical formulaC₁₅₂H₂₃₉N₅₅O₃₆
          Hygroscopic Hygroscopic
          ReversibleY
          Applications
          Biological Information
          Primary TargetAkt
          Primary Target IC<sub>50</sub>50 µM against Akt
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          124014

          References

          Reference overview
          Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-November-2014 JSW
          SynonymsH-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1₁₀₋₂₄
          DescriptionA cell-permeable and reversible version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT. Selectively inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells and tumor growth in syngeneic C57BL/6 mice at 2 µM/mouse without any adverse effect.
          FormWhite solid
          FormulationSupplied as an trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₅₂H₂₃₉N₅₅O₃₆
          Peptide SequenceH-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesHiromura, M., et al. 2004. J. Biol. Chem. 279, 53407.