121800 | Advanced Glycation Endproduct-BSA

121800
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      121800-10MG
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          Glass bottle 10 mg
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          Description
          OverviewPrepared by reacting BSA with glycoaldehyde under sterile conditions. Glycated-BSA shows a 5,000 - 10,000% increase in fluorescence as compared to normal BSA (confirmed by fluorescence spectrophotometry, excitation/emission 370/440 nm). AGE-BSA has been reported to induce apoptosis in cultured human umbilical vein endothelial cells and inhibit nitric oxide synthase activity in proximal tubular epithelial cells. Advanced glycation end products and their receptors have been implicated in the pathogenesis of diabetes, induction of proinflammatory cytokines, and stimulation of smooth muscle proliferation, and fibronectin production.
          Catalogue Number121800
          Brand Family Calbiochem®
          SynonymsAGE-BSA
          References
          ReferencesOkamoto, T., et al. 2002. Microvasc. Res. 63, 186.
          Ohgami, N., et al. 2001. J. Biol. Chem. 276, 3195.
          Wang, R., et al. 2001. J. Nippon Med. Sch. 68, 472.
          Sakata, N., et al. 2000. J. Atheroscler. Thromb. 7, 169.
          Verbeke, P., et al. 2000. Biochim. Biophys. Acta 1502, 481.
          Farboud, B., et al. 1999. Mol. Vis. 5, 11.
          Huang, J.-S., et al. 1999. Biochem. J. 342, 231.
          Min, C., et al. 1999. Diabetes Res. Clin. Pract. 46, 197.
          Neumann, A., et al. 1999. FEBS Lett. 453, 283.
          Stitt, A.W., et al. 1999. Biochem. Biophys. Res. Commun. 256, 549.
          Nazaimoon, W. and Bak, K. 1998. Malays. J. Pathol. 20, 83.
          Product Information
          FormLiquid
          FormulationIn sterile-filtered PBS.
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          121800

          References

          Reference overview
          Okamoto, T., et al. 2002. Microvasc. Res. 63, 186.
          Ohgami, N., et al. 2001. J. Biol. Chem. 276, 3195.
          Wang, R., et al. 2001. J. Nippon Med. Sch. 68, 472.
          Sakata, N., et al. 2000. J. Atheroscler. Thromb. 7, 169.
          Verbeke, P., et al. 2000. Biochim. Biophys. Acta 1502, 481.
          Farboud, B., et al. 1999. Mol. Vis. 5, 11.
          Huang, J.-S., et al. 1999. Biochem. J. 342, 231.
          Min, C., et al. 1999. Diabetes Res. Clin. Pract. 46, 197.
          Neumann, A., et al. 1999. FEBS Lett. 453, 283.
          Stitt, A.W., et al. 1999. Biochem. Biophys. Res. Commun. 256, 549.
          Nazaimoon, W. and Bak, K. 1998. Malays. J. Pathol. 20, 83.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-April-2008 RFH
          SynonymsAGE-BSA
          DescriptionPrepared by reacting bovine serum albumin (BSA) with glycoaldehyde under sterile conditions. Fluorescence of AGE-BSA is confirmed by fluorescence spectrophotometry, excitation/emission = 370/440 nm. Glycated BSA shows a 5000-10,000% increase in fluorescence compared to control BSA. AGE and their receptors have been implicated in the pathogenesis of diabetes, induction of pro-inflammatory cytokines, and stimulation of smooth muscle proliferation and fibronectin production. AGE-BSA has also been shown to induce apoptosis in cultured human umbilical vein endothelial cells (HUVEC) and inhibit nitric oxide synthase activity in proximal tubular epithelial cells of the kidney.
          FormLiquid
          FormulationIn sterile-filtered PBS.
          Concentration Label Please refer to vial label for lot-specific concentration
          Purity≥95% by SDS-PAGE
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesOkamoto, T., et al. 2002. Microvasc. Res. 63, 186.
          Ohgami, N., et al. 2001. J. Biol. Chem. 276, 3195.
          Wang, R., et al. 2001. J. Nippon Med. Sch. 68, 472.
          Sakata, N., et al. 2000. J. Atheroscler. Thromb. 7, 169.
          Verbeke, P., et al. 2000. Biochim. Biophys. Acta 1502, 481.
          Farboud, B., et al. 1999. Mol. Vis. 5, 11.
          Huang, J.-S., et al. 1999. Biochem. J. 342, 231.
          Min, C., et al. 1999. Diabetes Res. Clin. Pract. 46, 197.
          Neumann, A., et al. 1999. FEBS Lett. 453, 283.
          Stitt, A.W., et al. 1999. Biochem. Biophys. Res. Commun. 256, 549.
          Nazaimoon, W. and Bak, K. 1998. Malays. J. Pathol. 20, 83.