505855 Adenovirus Proteinase Inhibitor, NSC 37249 - CAS 2907-88-2 - Calbiochem

505855
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₀H₅₈N₄O₄S 2907-88-2

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      5.05855.0001
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          Glass bottle 10 mg
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          Description
          OverviewA sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus cysteine proteinase AVP by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM), blocking both AVP-pVIc active complex formation (IC50 = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM) and catalytic activity (IC50 = 490 nM; [substrate] = 5 µM) without affecting trypsin or papain protease activity even at concentrations as high as 10 µM.
          Catalogue Number505855
          Brand Family Calbiochem®
          Synonyms2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide, AVP Inhibitor
          References
          ReferencesMcGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.
          Product Information
          CAS number2907-88-2
          FormOff-white powder
          Hill FormulaC₄₀H₅₈N₄O₄S
          Chemical formulaC₄₀H₅₈N₄O₄S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket
          Secondary targetAVP-pVIc substrate-binding site
          Purity≥90% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          McGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-January-2014 JSW
          Synonyms2-(Dicyclohexylamino)-N-(4-(4-((2-(dicyclohexylamino)acetyl)amino)phenyl)sulfonylphenyl)acetamide, N,Nʹ-(Sulfonyldi-4,1-phenylene)bis(2-(dicyclohexylamino)acetamide, AVP Inhibitor
          DescriptionA sulfonyldiphenylene-bis-dicyclohexylaminoacetamide compound that acts as a potent and selective inhibitor against adenovirus AVP, the cysteine proteinase critical for virion assembly and maturation, by targeting simultaneously AVP co-factor pVIc (GVQSLKRRRCF) N-terminal binding pocket (Ki = 150 nM) and AVP-pVIc substrate-binding site (Ki = 400 nM), blocking not only AVP-pVIc active complex formation/AVP activation (IC50 = 140 nM; [substrate] = 5 µM & [pVIc] = 40 µM), but also AVP-pVIc active complex catalytic activity (IC50 = 490 nM; [substrate] = 5 µM). Does not affect the activity of the serine protease trypsin or the cysteine protease papain even at concentrations as high as 10 µM.
          FormOff-white powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2907-88-2
          Chemical formulaC₄₀H₅₈N₄O₄S
          Structure formulaStructure formula
          Purity≥90% by HPLC
          Solubility5% TFA in EtOH (5 mg/ml). Not soluble in DMSO.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesMcGrath, W.J., et al. 2013. FEBS Lett. 587, 2332.