114700 | Activin A, Human, Recombinant, CHO Cells

114700
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      Overview

      Replacement Information

      Key Specifications Table

      Purity
      ≥95% by SDS-PAGE

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      114700-10UG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
        Remaining : Will advise
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          Will advise
          Contact Customer Service

          Plastic ampoule 10 μg
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          Description
          OverviewRecombinant, human activin A (disulfide-linked homodimer of two 116-amino acid residue βA subunits) expressed in CHO cells. Mature βA-monomer lacks a potential N-linked glycosylation site and has a calculated molecular weight of 13 kDa. A member of the TGF-β superfamily that is involved in the negative regulation of B lineage lymphocytes. Shown to play an important role in the regulation of hormonogenesis, cellular homeostasis, and differentiation programs. Reported to inhibit endogenous production of IL-6.
          Catalogue Number114700
          Brand Family Calbiochem®
          References
          ReferencesZipori, D., et al. 2001. J. Leukoc. Biol. 69, 867.
          Hedger, M.P., et al. 2000. Cytokine 12, 595.
          Woodruff, T.K. 1998. Biochem. Pharmacol. 55, 953.
          Ying, S.Y., et al. 1997. Proc. Soc. Exp. Biol. Med. 214, 114.
          Schwall, R.H., and Lei, C. 1991. Methods Enzymol. 198, 340.
          Mason, A., et al. 1986. Biochem. Biophys. Res. Commun. 135, 957.
          Product Information
          FormLyophilized
          FormulationLyophilized from sterile filtered 35% acetonitrile, 0.1% TFA, 50 µg BSA/µg Activin A.
          Applications
          Biological Information
          Biological activityED₅₀ = 0.5-2.0 ng/ml as measured by its ability to induce hemoglobin expression in K562 cells
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxin: ≤100 pg/µg Activin A
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          114700

          References

          Reference overview
          Zipori, D., et al. 2001. J. Leukoc. Biol. 69, 867.
          Hedger, M.P., et al. 2000. Cytokine 12, 595.
          Woodruff, T.K. 1998. Biochem. Pharmacol. 55, 953.
          Ying, S.Y., et al. 1997. Proc. Soc. Exp. Biol. Med. 214, 114.
          Schwall, R.H., and Lei, C. 1991. Methods Enzymol. 198, 340.
          Mason, A., et al. 1986. Biochem. Biophys. Res. Commun. 135, 957.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-April-2008 RFH
          DescriptionRecombinant, human activin A (disulfide-linked homodimer of two 116-amino acid residue βA subunits) expressed in CHO cells. Mature βA-monomer lacks a potential N-linked glycosylation site and has a calculated molecular mass of 13 kDa. Activins are members of the TGF-β superfamily and have been shown to play an important role in the regulation of homonogenesis, cellular homeostasis, and differentiation programs.
          FormLyophilized
          FormulationLyophilized from sterile filtered 35% acetonitrile, 0.1% TFA, 50 µg BSA/µg Activin A.
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxin: ≤100 pg/µg Activin A
          Biological activityED₅₀ = 0.5-2.0 ng/ml as measured by its ability to induce hemoglobin expression in K562 cells
          SolubilityReconstitute to a concentration ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
          Storage ≤ -70°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
          Toxicity Standard Handling
          ReferencesZipori, D., et al. 2001. J. Leukoc. Biol. 69, 867.
          Hedger, M.P., et al. 2000. Cytokine 12, 595.
          Woodruff, T.K. 1998. Biochem. Pharmacol. 55, 953.
          Ying, S.Y., et al. 1997. Proc. Soc. Exp. Biol. Med. 214, 114.
          Schwall, R.H., and Lei, C. 1991. Methods Enzymol. 198, 340.
          Mason, A., et al. 1986. Biochem. Biophys. Res. Commun. 135, 957.