208721 | ALLM - CAS 110115-07-6 - Calbiochem

208721
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₃₅N₃O₄S 110115-07-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208721-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewCell permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 600 pM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A weak inhibitor of proteasome.
          Catalogue Number208721
          Brand Family Calbiochem®
          SynonymsCalpain Inhibitor II
          References
          ReferencesRavid, T., et al. 2000. J. Biol. Chem. 275, 35840.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Sarin, A., et al. 1994. J. Immunol. 153, 862.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
          Koohmaraie, M. 1992. Biochemie 74, 239.
          Pinter, M., et al. 1992. Biochemistry 31, 8201.
          Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
          Product Information
          CAS number110115-07-6
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₁₉H₃₅N₃O₄S
          Chemical formulaC₁₉H₃₅N₃O₄S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcalpain-1
          Primary Target K<sub>i</sub>120 nM, 230 nM, 100 nM, and 600 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
          Purity>95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceN-Acetyl-Leu-Leu-Met
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208721

          References

          Reference overview
          Ravid, T., et al. 2000. J. Biol. Chem. 275, 35840.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Sarin, A., et al. 1994. J. Immunol. 153, 862.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
          Koohmaraie, M. 1992. Biochemie 74, 239.
          Pinter, M., et al. 1992. Biochemistry 31, 8201.
          Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Nitric Oxide and Oxidative Stress Brochure
          Proteasomes Technical Bulletin

          Citations

          Title
        • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision03-October-2007 RFH
          SynonymsCalpain Inhibitor II
          DescriptionA cell-permeable inhibitor of calpain I (Ki = 120 nM), calpain II (Ki = 230 nM), cathepsin B (Ki = 100 nM), and cathepsin L (Ki = 0.6 nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide produced by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
          FormOff-white solid
          CAS number110115-07-6
          Chemical formulaC₁₉H₃₅N₃O₄S
          Peptide SequenceN-Acetyl-Leu-Leu-Met
          Structure formulaStructure formula
          Purity>95% by HPLC
          SolubilityDMSO (5 mg/ml), Ethanol (5 mg/ml), and Methanol (5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesRavid, T., et al. 2000. J. Biol. Chem. 275, 35840.
          Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
          Sarin, A., et al. 1994. J. Immunol. 153, 862.
          Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
          Banik, N.L., et al. 1992. Neurochem. Res. 17, 797.
          Koohmaraie, M. 1992. Biochemie 74, 239.
          Pinter, M., et al. 1992. Biochemistry 31, 8201.
          Shenoy, A.M., and Brahmi, Z. 1991. Cell. Immunol. 138, 24.
          Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.
          Citation
        • Masako Shimada, et al. (2005) The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology 146, 2336-2344.
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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors
          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors