407294 αA-Interferon, Human, Recombinant, E. coli

407294
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      407294-5MU
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          Plastic ampoule 5 mu
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          Description
          OverviewRecombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential with chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer. NOTE: 1MU = 1,000,000 units.
          Note: 1 MU = 1,000,000 units.
          Catalogue Number407294
          Brand Family Calbiochem®
          SynonymsrhIFN-αA
          References
          ReferencesFujishima, H., et al. 1998. Int. J. Cancer 76, 423.
          Haria, M., and Benfield, P. 1995. Drugs 50, 873.
          Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
          Product Information
          Activity≥5 x 10⁶ units/ml
          Unit of DefinitionOne unit of interferon per ml of medium will cause a 50% inhibition of VSV-induced cytopathic effect on bovine MDBK cells. Units are determined with respect to the NIH international reference standard for human αA-IFN. Dilute in aqueous buffer containing at least 0.1% BSA or HSA.
          FormLiquid
          FormulationIn PBS containing 0.1% BSA.
          Applications
          Biological Information
          Purity≥95% by SDS-PAGE
          Specific Activity≥2.8 x 10⁸ units/mg protein
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          407294

          References

          Reference overview
          Fujishima, H., et al. 1998. Int. J. Cancer 76, 423.
          Haria, M., and Benfield, P. 1995. Drugs 50, 873.
          Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.

          Brochure

          Title
          Growth Factors and Cytokines Technical Bulletin

          Citations

          Title
        • Sambit K. Nanda and Michael D. Baron. (2006) Rinderpest virus blocks type I and type II interferon action: role of structural and nonstructural proteins. Journal of Virology 80, 7555-7568.
        • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-May-2008 RFH
          SynonymsrhIFN-αA
          DescriptionRecombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential in chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer.
          FormLiquid
          FormulationIn PBS containing 0.1% BSA.
          Purity≥95% by SDS-PAGE
          Specific activity≥2.8 x 10⁸ units/mg protein
          Activity≥5 x 10⁶ units/ml
          Unit definitionOne unit of interferon per ml of medium will cause a 50% inhibition of VSV-induced cytopathic effect on bovine MDBK cells. Units are determined with respect to the NIH international reference standard for human αA-IFN. Dilute in aqueous buffer containing at least 0.1% BSA or HSA.
          SolubilityDilute only in buffers containing protein such as 0.1% BSA.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          Merck USA index14, 4990
          ReferencesFujishima, H., et al. 1998. Int. J. Cancer 76, 423.
          Haria, M., and Benfield, P. 1995. Drugs 50, 873.
          Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.
          Citation
        • Sambit K. Nanda and Michael D. Baron. (2006) Rinderpest virus blocks type I and type II interferon action: role of structural and nonstructural proteins. Journal of Virology 80, 7555-7568.
        • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
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          Categories

          Life Science Research > Proteins and Enzymes > Other Proteins