508505 | A-803467 - CAS 944261-79-4 - Calbiochem

508505
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₁₆ClNO₄ 944261-79-4

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.08505.0001
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          Glass bottle 10 mg
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          Description
          OverviewA voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥ 1 µM).
          Catalogue Number508505
          Brand Family Calbiochem®
          SynonymsSodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
          References
          ReferencesJarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.
          Product Information
          CAS number944261-79-4
          FormWhite solid
          Hill FormulaC₁₉H₁₆ClNO₄
          Chemical formulaC₁₉H₁₆ClNO₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNav1.8
          Primary Target IC<sub>50</sub>8 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-January-2014 JSW
          SynonymsSodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
          DescriptionA voltage gated sodium channel type 1.8 (Nav1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC50) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Nav1.8 (IC50 = 8 nM) and was >100-fold selective vs. human Nav1.2, Nav1.3, Nav1.5, and Nav1.7 (IC50 values ≥ 1 µM).
          FormWhite solid
          CAS number944261-79-4
          Chemical formulaC₁₉H₁₆ClNO₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mM) or EtOH (25 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesJarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8520.