505315 | A 438079 - CAS 899507-36-9 - Calbiochem

505315
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₉Cl₂N₅•HCl 899507-36-9

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05315.0001
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          Glass bottle 10 mg
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          Description
          OverviewA potent, competitive, and selective antagonist of P2X7 purinergic receptor (pIC50 = 6.5 nM and 6.9 nM for rat and human P2X7 receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10 µM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC50 = 100 and 300 nM at rat and human P2X7 receptors, respectively.
          Catalogue Number505315
          Brand Family Calbiochem®
          Synonyms3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride, P2X7 Purinergic Receptor Antagonist, A 438079, A438079, A-438079
          References
          ReferencesDonnelly-Roberts, et al., 2007, Br. J. Pharmacol. 101, 571.
          Wang B, et al., 2013, Purinergic Signal. 9, 101.
          Product Information
          CAS number899507-36-9
          FormOff-white solid
          Hill FormulaC₁₃H₉Cl₂N₅•HCl
          Chemical formulaC₁₃H₉Cl₂N₅•HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP2X₇
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Donnelly-Roberts, et al., 2007, Br. J. Pharmacol. 101, 571.
          Wang B, et al., 2013, Purinergic Signal. 9, 101.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          Synonyms3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride, P2X7 Purinergic Receptor Antagonist, A 438079, A438079, A-438079
          DescriptionA potent, competitive, and selective antagonist of P2X7 purinergic receptor (pIC50 = 6.5 nM and 6.9 nM for rat and human P2X7 receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10 µM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC50 = 100 and 300 nM at rat and human P2X7 receptors, respectively.
          FormOff-white solid
          CAS number899507-36-9
          Chemical formulaC₁₃H₉Cl₂N₅•HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesDonnelly-Roberts, et al., 2007, Br. J. Pharmacol. 101, 571.
          Wang B, et al., 2013, Purinergic Signal. 9, 101.