499610 (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

499610
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₂O₇ 66018-38-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      499610-1MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          Glass bottle 1 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.
          Catalogue Number499610
          Brand Family Calbiochem®
          SynonymsTAK1 Inhibitor
          References
          ReferencesWindheim, M., et al. 2007. Biochem. J. 404, 179.
          Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
          Safwat, N., et al. 2005. Endocrinology 146, 4814.
          Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
          Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.
          Product Information
          CAS number66018-38-0
          FormWhite solid
          Hill FormulaC₁₉H₂₂O₇
          Chemical formulaC₁₉H₂₂O₇
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          499610

          References

          Reference overview
          Windheim, M., et al. 2007. Biochem. J. 404, 179.
          Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
          Safwat, N., et al. 2005. Endocrinology 146, 4814.
          Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
          Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-June-2009 JSW
          SynonymsTAK1 Inhibitor
          DescriptionA naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp.(Cat. No. 499609) may serve as a negative control.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number66018-38-0
          Chemical formulaC₁₉H₂₂O₇
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesWindheim, M., et al. 2007. Biochem. J. 404, 179.
          Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
          Safwat, N., et al. 2005. Endocrinology 146, 4814.
          Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
          Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.