505736 5-BDBD - CAS 768404-03-1 - Calbiochem

505736
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₁BrN₂O₂ 768404-03-1

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      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      5.05736.0001
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          Glass bottle 5 mg
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          Description
          OverviewA highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
          Catalogue Number505736
          Brand Family Calbiochem®
          Synonyms5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
          References
          ReferencesTrabanelli, S., et al. 2012. J. Immunol. 189, 1303.
          Wu, T., et al. 2011. Am. J. Physiol. 301, H69.
          Product Information
          CAS number 768404-03-1
          FormOff-white powder
          Hill FormulaC₁₇H₁₁BrN₂O₂
          Chemical formulaC₁₇H₁₁BrN₂O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetP2X₄
          Primary Target IC<sub>50</sub>500 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Trabanelli, S., et al. 2012. J. Immunol. 189, 1303.
          Wu, T., et al. 2011. Am. J. Physiol. 301, H69.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-September-2013 JSW
          Synonyms5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one, P2X4 Purinergic Receptor Antagonist, 5-BDBD
          DescriptionA highly potent antagonist of purinergic P2X4 receptor. Shown to block P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 500 nM). Blocks ATP-induced dilation of spiral ligament capillaries in guinea pigs. Also shown to restore the viability of activated CD4+ cells in the presence of 1 mM ATP.
          FormOff-white powder
          CAS number 768404-03-1
          Chemical formulaC₁₇H₁₁BrN₂O₂
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (15 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTrabanelli, S., et al. 2012. J. Immunol. 189, 1303.
          Wu, T., et al. 2011. Am. J. Physiol. 301, H69.