238900 | 4-Cyano-3-methylisoquinoline

238900
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₁H₈N₂ 161468-32-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      238900-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.
          Catalogue Number238900
          Brand Family Calbiochem®
          SynonymsPKA Inhibitor XI
          References
          ReferencesLu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.
          Product Information
          CAS number161468-32-2
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₁H₈N₂
          Chemical formulaC₁₁H₈N₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKA
          Primary Target IC<sub>50</sub>30 nM against protein kinase A
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          238900

          References

          Reference overview
          Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2011 RFH
          SynonymsPKA Inhibitor XI
          DescriptionA potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number161468-32-2
          Chemical formulaC₁₁H₈N₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.