475250 | 4-{[3ʹ,4ʹ-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline

475250
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₇H₁₅N₃O₃

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      475250-5MG
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          Glass bottle 5 mg
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          Description
          OverviewPotent and specific inhibitor of cGMP-specific phosphodiesterase (PDE V; IC50 = 230 nM). Elevates the intracellular cGMP level without causing any change in the cAMP level in isolated porcine coronary arteries. Has no effect on other PDE isozymes.
          Catalogue Number475250
          Brand Family Calbiochem®
          References
          ReferencesTakase, Y., et al. 1994. J. Med. Chem. 37, 2106.
          Product Information
          FormWhite solid
          Hill FormulaC₁₇H₁₅N₃O₃
          Chemical formulaC₁₇H₁₅N₃O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCGMP-PDEV
          Primary Target IC<sub>50</sub>230 nM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          475250

          References

          Reference overview
          Takase, Y., et al. 1994. J. Med. Chem. 37, 2106.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-July-2009 RFH
          DescriptionPotent and specific inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50 = 230 nM). Elevates the intracellular cGMP level without causing a change in the cAMP level in isolated porcine coronary arteries. Has no effect on other PDE isoenzymes.
          FormWhite solid
          Chemical formulaC₁₇H₁₅N₃O₃
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Toxicity Standard Handling
          ReferencesTakase, Y., et al. 1994. J. Med. Chem. 37, 2106.