288104 | 2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem

288104
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀H₁₃N₅O₂ 6698-26-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      288104-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewCell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of β-adrenergic agents.
          Catalogue Number288104
          Brand Family Calbiochem®
          Synonyms2ʹ,5ʹ-dd-Ado
          References
          ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
          Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
          Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
          Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
          Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
          Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
          Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.
          Product Information
          CAS number6698-26-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₀H₁₃N₅O₂
          Chemical formulaC₁₀H₁₃N₅O₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetadenylate cyclase
          Primary Target IC<sub>50</sub>3 µM against adenylate cyclase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          288104

          References

          Reference overview
          Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
          Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
          Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
          Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
          Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
          Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
          Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-June-2008 RFH
          Synonyms2ʹ,5ʹ-dd-Ado
          DescriptionMembrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC50 = 3 µM for detergent solubilized rat brain membranes; IC50 = 45 µM for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC50 = 540 µM) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of β-adrenergic agents.
          FormWhite solid
          CAS number6698-26-6
          Chemical formulaC₁₀H₁₃N₅O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
          Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
          Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
          Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
          Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
          Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
          Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.