454180 | 2-Methoxyestradiol - CAS 362-07-2 - Calbiochem

454180
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₆O₃ 362-07-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      454180-10MG
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          Alu drum 10 mg
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          454180-50MG
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              Alu drum 50 mg
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              Description
              OverviewA natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits the neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin, and has been suggested to function as a natural regulator of microtubule assembly and function.
              Catalogue Number454180
              Brand Family Calbiochem®
              Synonyms2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene
              References
              ReferencesAizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
              Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
              D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
              Forsis, T., et al. 1994. Nature 368, 237.
              Product Information
              CAS number362-07-2
              ATP CompetitiveN
              FormWhite crystalline solid
              Hill FormulaC₁₉H₂₆O₃
              Chemical formulaC₁₉H₂₆O₃
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetInhibits cell proliferation and angiogenesis
              Purity≥90% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 23/24/25-36/37/38

              Toxic by inhalation, in contact with skin and if swallowed.
              Irritating to eyes, respiratory system and skin.
              S PhraseS: 22-26-36/37/39-45

              Do not breathe dust.
              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing, gloves and eye/face protection.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Toxic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage +15°C to +30°C
              Do not freeze Ok to freeze
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              454180

              References

              Reference overview
              Aizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
              Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
              D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
              Forsis, T., et al. 1994. Nature 368, 237.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision15-May-2008 RFH
              Synonyms2-Methoxy-3,17β-dihydroxyestra-1,3,5(10)-triene
              DescriptionA natural metabolite of 17β-estradiol that is devoid of estrogenic activity. Inhibits cell proliferation and angiogenesis. Markedly inhibits neovascularization of solid tumors and suppresses tumor growth in mice. Binds to the colchicine binding site of tubulin and has been suggested to function as a natural regulator of microtubule assembly and function.
              FormWhite crystalline solid
              CAS number362-07-2
              Chemical formulaC₁₉H₂₆O₃
              Structure formulaStructure formula
              Purity≥90% by HPLC
              SolubilityDMSO or Ethanol
              Storage +15°C to +30°C
              Do Not Freeze Ok to freeze
              Toxicity Toxic
              ReferencesAizu-Yokata, E., et al. 1995. Cancer Res. 55, 1863.
              Cushman, M., et al. 1995. J. Med. Chem. 38, 2041.
              D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3964.
              Forsis, T., et al. 1994. Nature 368, 237.