126850 | α₁-PDX, Human, Recombinant, E. coli - Calbiochem

126850
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      126850-2.5MG
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          Plastic ampoule 2.5 mg
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          Description
          OverviewRecombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His•Tag® sequence and a FLAG®-tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). Extracellular application of α1-PDX can be used to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors. Useful for in vivo and in vitro furin inhibition assays.
          Catalogue Number126850
          Brand Family Calbiochem®
          Synonymsα₁-Antitrypsin Portland
          References
          ReferencesBassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
          Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
          Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.
          Product Information
          ATP CompetitiveN
          FormLyophilized solid
          FormulationLyophilized from PBS.
          ReversibleN
          Applications
          Biological Information
          Primary TargetFurin-dependent processing of protein precursors
          Primary Target K<sub>i</sub>600 pM against furin-dependent processing of protein precursors
          Purity≥80% by SDS-PAGE
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Yes
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          126850

          References

          Reference overview
          Bassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
          Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
          Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2008 JSW
          Synonymsα₁-Antitrypsin Portland
          DescriptionRecombinant protein derived from the bioengineered human α1-antitrypsin gene fused to a His·Tag® and a FLAG·Tag. Contains a minimal furin consensus sequence, RXXR, that effectively blocks the furin-dependent processing of protein precursors (Ki = 600 pM). α1-PDX can be used in extracellular applications to block the processing of furin substrates. α1-PDX has been shown to inhibit the processing of biologically significant proteins including viral envelope glycoproteins, bacterial toxins, receptors, and growth factors.
          FormLyophilized solid
          FormulationLyophilized from PBS.
          Concentration Label Please refer to vial label for lot-specific concentration
          Purity≥80% by SDS-PAGE
          SolubilityH₂O (2.5 mg/ml)
          Storage +2°C to +8°C
          Do Not Freeze Yes
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBassi, D.E., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 10326.
          Jean, F., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2864.
          Jean, F., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 7293.