191500 | 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

191500
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₁₀BrN₃O 676596-65-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      191500-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM), and displays ~100-200 fold greater selectivity over Cdk1/B and Cdk5/p25 (IC50 = 2 µM and 4.2 µM, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 191501).
          Catalogue Number191500
          Brand Family Calbiochem®
          Synonyms1-AKP
          References
          ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
          Product Information
          CAS number676596-65-9
          ATP CompetitiveY
          FormTan solid
          Hill FormulaC₁₅H₁₀BrN₃O
          Chemical formulaC₁₅H₁₀BrN₃O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGSK-3β
          Primary Target IC<sub>50</sub>18 nM against GSK-3β
          Purity≥94% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          191500

          References

          Reference overview
          Kunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-December-2010 JSW
          Synonyms1-AKP
          DescriptionA Kenpaullone (Cat. No. 422000) analog that acts as a potent and ATP-competitive inhibitor of GSK-3β (IC50 = 18 nM). Displays over 100-fold greater selectivity over Cdk1/cyclin B and Cdk5/p25 (IC50 = 2.0 µM and 4.2 µM, respectively).
          FormTan solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number676596-65-9
          Chemical formulaC₁₅H₁₀BrN₃O
          Structure formulaStructure formula
          Purity≥94% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKunick, C., et al. 2004. Bioorg. Med. Chem. Lett. 14, 413.