178251 α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem

178251
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #
      9041-92-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      178251-1MG
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          Glass bottle 1 mg
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          178251-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase. Inhibitor of neutrophil elastase, cathepsin G, and proteinase 3.
              Catalogue Number178251
              Brand Family Calbiochem®
              Synonymsα₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein
              References
              ReferencesCoakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
              Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.
              Product Information
              CAS number9041-92-3
              Activity≥75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.
              ATP CompetitiveN
              FormSolid
              FormulationLyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.
              ReversibleN
              Applications
              Biological Information
              Primary Targetserine proteases
              Purity≥95% by SDS-PAGE
              SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              178251

              References

              Reference overview
              Coakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
              Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision15-April-2008 RFH
              Synonymsα₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein
              DescriptionA single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues. Present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase.
              FormSolid
              FormulationLyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.
              SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
              CAS number9041-92-3
              Purity≥95% by SDS-PAGE
              Activity≥75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.
              SolubilityH₂O. Please refer to vial label for lot-specific volume prior to lyophilization.
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
              Toxicity Standard Handling
              Merck USA index14, 719
              ReferencesCoakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
              Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.