401003 | (±)-Ibuprofen - CAS 15687-27-1 - Calbiochem

401003
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₃H₁₈O₂ 15687-27-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      401003-1GM
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          Plastic ampoule 1 gm
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          Description
          OverviewA nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible and competitive inhibitor of cyclooxygenase 1 (COX-1) (IC50 = 4.85 µM). Inhibits COX-2 at higher concentrations (IC50 = 223 µM). Blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µM aspirin = 290 nM). Shown to reduce the total Aβ secretion (Amyloid β40 and 42) in human neuronal cells and offers neuroprotection against glutamate-, nitric oxide-, and superoxide-induced damage. Reported to activate peroxisome proliferator-activated receptors (PPAR) α and γ in both CV-1 and C3H10T1/2 cells (~100 µM-500 µM).
          Catalogue Number401003
          Brand Family Calbiochem®
          Synonyms[(±)-2-(4-Isobutylphenyl)-propionic Acid
          References
          ReferencesAsanuma, M., et al. 2001. J. Neurochem. 76, 1895.
          Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094.
          Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583.
          Casper, D., et al. 2000. Neurosci. Lett. 289, 201.
          Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249.
          Lim, G.P., et al. 2000. J. Neurosci. 20, 5709.
          Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137.
          Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973.
          Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406.
          Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S.
          Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.
          Product Information
          CAS number15687-27-1
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₃H₁₈O₂
          Chemical formulaC₁₃H₁₈O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCOX-1
          Primary Target IC<sub>50</sub>4.85 µM against COX-1
          Purity≥98% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMU6640000
          Safety Information
          R PhraseR: 22

          Harmful if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +15°C to +30°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          401003

          References

          Reference overview
          Asanuma, M., et al. 2001. J. Neurochem. 76, 1895.
          Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094.
          Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583.
          Casper, D., et al. 2000. Neurosci. Lett. 289, 201.
          Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249.
          Lim, G.P., et al. 2000. J. Neurosci. 20, 5709.
          Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137.
          Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973.
          Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406.
          Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S.
          Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 JSW
          Synonyms[(±)-2-(4-Isobutylphenyl)-propionic Acid
          DescriptionA nonsteroidal anti-inflammatory drug (NSAID) that acts as a reversible, competitive, non-selective cyclooxygenase (COX) inhibitor (IC50 = 4.85 µM for purified COX-1 and 223 µM for purified COX-2). Also reported to inhibit COX-1 and COX-2 activity in intact bovine aortic endothelial cells (BAEC) (IC50 = 7 µM for COX-1 and 72.7 µM for COX-2). Potently blocks aspirin inactivation of COX-1 (EC50 antagonism of 200 µM aspirin ~290 nM for ovine COX-1). Decreases the secretion of total Aβ (Amyloid β40&42) by human neuronal cells and offers neuroprotection against glutamate-, nitric oxide- and superoxide-induced damage. Activates peroxisome proliferator activated receptors α and γ in both CV-1 and C3H10T1/2 cells (~100 µM - 500 µM).
          FormWhite solid
          CAS number15687-27-1
          RTECSMU6640000
          Chemical formulaC₁₃H₁₈O₂
          Structure formulaStructure formula
          Purity≥98% by titration
          SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
          Storage +15°C to +30°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 4881
          ReferencesAsanuma, M., et al. 2001. J. Neurochem. 76, 1895.
          Blasko, I., et al. 2001. Neurobiol. Dis. 8, 1094.
          Ouellet, M., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14583.
          Casper, D., et al. 2000. Neurosci. Lett. 289, 201.
          Lambat, Z., et al. 2000. Metab. Brain Dis. 15, 249.
          Lim, G.P., et al. 2000. J. Neurosci. 20, 5709.
          Ogawa, O., et al. 2000. Eur. J. Pharmacol. 408, 137.
          Wyss-Coray, T., and Mucke, L. 2000. Nat. Med. 6, 973.
          Lehmann, J.M., et al. 1997. J. Biol. Chem. 272, 3406.
          Boneburg, E.M., et al. 1996. J. Clin. Pharmacol. 36, 16S.
          Mitchell, J.A., et al. 1994. Proc. Natl. Acad. Sci. USA 90, 11693.