343781 | ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem

343781
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂₀H₁₈₂N₃₈O₄₃S₆ 106375-28-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      343781-100UG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Alu drum 100 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
          Catalogue Number343781
          Brand Family Calbiochem®
          Synonymsω-CgTx GVIA
          References
          ReferencesLalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
          Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
          Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
          Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
          Protti, D.A., et al. 1991. Brain Res. 557, 336.
          Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
          Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
          Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
          Product Information
          CAS number106375-28-4
          ATP CompetitiveN
          DeclarationNot available for sale outside of the United States.
          FormLyophilized
          Hill FormulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
          Chemical formulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
          ReversibleN
          Applications
          Biological Information
          Primary TargetVoltage-activated N-type Ca2+ channels
          Primary Target IC<sub>50</sub>21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 45-36/37/39

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          End use certificateY
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          343781

          References

          Reference overview
          Lalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
          Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
          Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
          Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
          Protti, D.A., et al. 1991. Brain Res. 557, 336.
          Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
          Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
          Abe, T., et al. 1986. Neurosci. Lett. 71, 203.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2008 RFH
          Synonymsω-CgTx GVIA
          DescriptionA neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
          FormLyophilized
          CAS number106375-28-4
          Chemical formulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
          Peptide SequenceH-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
          Purity≥98% by HPLC
          SolubilityH₂O (250 µg/ml) or aqueous buffers
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Highly Toxic
          ReferencesLalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
          Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
          Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
          Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
          Protti, D.A., et al. 1991. Brain Res. 557, 336.
          Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
          Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
          Abe, T., et al. 1986. Neurosci. Lett. 71, 203.