196878 (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem

196878
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₅F₃N₂O₄ 93468-89-4
      Description
      OverviewSynthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
      Catalogue Number196878
      Brand Family Calbiochem®
      Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
      References
      ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
      Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
      Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
      Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
      Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
      Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
      Tagliatela, M., et al. 1986. Brain Res. 381, 356.
      Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
      Product Information
      CAS number93468-89-4
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₆H₁₅F₃N₂O₄
      Chemical formulaC₁₆H₁₅F₃N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetL-type Ca2+ channel
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      (±)-Bay K 8644 - CAS 93468-89-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      196878

      References

      Reference overview
      Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
      Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
      Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
      Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
      Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
      Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
      Tagliatela, M., et al. 1986. Brain Res. 381, 356.
      Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-February-2009 JSW
      Synonyms1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2ʹ-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester
      DescriptionA synthetic dihydropyridine derivative that is an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid, and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive ionotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weak vasodilating, negative ionotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.
      FormYellow solid
      CAS number93468-89-4
      Chemical formulaC₁₆H₁₅F₃N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol (35 mg/ml) or DMSO (35 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 20 days at 4°C.
      Toxicity Irritant
      ReferencesWang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427.
      Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461.
      Vannier, C., et al. 1995. Am. J. Physiol. 268, L201.
      Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343.
      Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507.
      Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107.
      Tagliatela, M., et al. 1986. Brain Res. 381, 356.
      Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.