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Description
Overview
A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y12 receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.
Liu, O., et al. 2012. PLoS One.7, e51707. Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A thienopyridine compound that acts as a specific irreversible inhibitor of purinergic P2Y12 receptors. Blocks ADP-induced platelet aggregation and serves as an anti-thrombotic agent. Shown to reduce vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. Clopidogrel is a prodrug that requires activation by CYP enzyme system to produce its pharmacologically active metabolite.
Form
White powder
CAS number
135046-48-9
Chemical formula
C₁₆H₁₆ClNO₂S•H₂SO₄
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (25 mg/ml)
Storage
+2°C to +8°C
Protect from light
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Liu, O., et al. 2012. PLoS One.7, e51707. Savi, P., et al. 2005. Semin. Thromb. Hemost.31, 174.