Protein Sample Concentration

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Sample Concentration Spotlight
Amicon® Pro Affinity Concentrator
Amicon® Pro Affinity Concentrator. Bind, wash, elute and concentrate your protein in the new all-in-one Amicon® Pro.Bind, wash, elute and concentrate your protein in the new all-in-one Amicon® Pro. 

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When downstream quality matters, make sure your upstream tools are the best. The last steps of preparing a protein sample for downstream analyses, such as activity assays or structural studies, involve ensuring that the protein is in its native, soluble form, dissolved in the buffer of choice, and at an appropriate concentration. MilliporeSigma’s membrane-based technologies, including tangential flow filtration (TFF)-based separation, enable fast, easy concentration, desalting and buffer exchange. 
Importance of TFF for concentration
Centrifuge and Rotor Recommendations
How to Concentrate Your Protein Samples
For reproducible protein assay results, you need to purify your protein of interest without denaturing it, losing its enzymatic activity or binding functions. Concentrate it without compromising yield, even if it’s labile or low in abundance. We offer several fast, gentle, membrane-based options for concentrating and fractionating your protein.

Nucleic Acid Concentration
Given the ever-increasing complexity of your genetic manipulations, purification and concentration of nucleic acids shouldn’t be a rate-limiting step. With our membrane-based technologies, you can eliminate time-consuming precipitation steps for clean, high yields of DNA or RNA. For higher throughput molecular biology, use our MultiScreen® plate-based tools that allow you to process up to 384 samples at once, either manually or using automation.

Virus Purification and Concentration
You’ve spent weeks optimizing the growth of your delicate target cells for viral infection. Now you need reliable, concentrated virus for efficient transduction and minimal toxicity. MilliporeSigma’s Fast-Trap® Virus Purification and Concentration kits let you purify and concentrate your virus in as little as two hours with excellent yield and purity. Achieve reproducibility at last by using Fast-Trap® kits for lentivirus, adenovirus or adeno-associated virus.