Chromabolt® Prepacked Columns

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Intelligently designed for ease of use in manufacturing facilities

Chromabolt® is a family of pre-validated columns prepacked with Merck Millipore chromatography resins, designed for early clinical stage manufacturing. Available in 3 sizes – 10, 20 and 32 cm inner diameter (i.d.), these prepacked columns free up end users valuable time and resources by eliminating manual packing and cleaning. With Chromabolt® prepacked columns, you can spend your time on manufacturing your products and not on laboriously packing chromatography resins.

Chromabolt® prepacked columns are characterized by:
  • Robust column design to withstand damage in everyday use
  • 20 cm and 32 cm i.d. columns on castors
  • Compatible with all currently available chromatography systems and connections

Merck Millipore’s Chromabolt® prepacked columns have been designed for use with our comprehensive chromatography resin portfolio. Using our established resins, automated column packing equipment and our extensive column packing knowledge, we can ensure that these prepacked columns will safely arrive at your facility within specification.

Resins available in Chromabolt® prepacked columns: More resins prepacked in Chromabolt® columns to come.

Shipping Studies

Critical to providing robust prepacked chromatography columns is the assurance that the columns will maintain resin specifications during shipping. Our extensive testing has demonstrated that we maintain a consistent packed bed at all three column sizes no matter what the shipping environment Chromabolt® columns are subjected to. All three sizes of columns are tested for HETP, Asymmetry and flow pre and post shipping under the ISTA-1E testing protocol.

Asymmetry pre- and post shipping for Fractogel® TMAE HiCap resin

Asymmetry was tested in 400mM NaCL pre- and post shipping on all three column sizes. Dashed red lines indicate specification. Asymmetry between 0.7-1.8

Each piece of the Chromabolt® column has been designed to safely and robustly purify drug products.

Click image to enlarge.

Ergonomics: Column Design

In addition to ensuring that the chromatography resin would maintain its performance characteristics in day-to-day operations, column engineering and design focused on making Chromabolt® columns:

  • intuitive to use
  • simple to wipe clean
  • easy for one person to transport

Time Savings: Column Economics

The advantages of fast turnaround time for Chromabolt® columns are demonstrated when comparing the hours required for setup and cleaning of traditional hardware columns as compared to a prepacked column.

Estimated time savings assuming packing of resin is successful on the first try

Click image to enlarge


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