Millipore Express SHF Hydrophilic Cartridge Filters

Sterilizing-grade PES membrane for fast, efficient, economical buffer filtration

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Cartouches avec joints toriques en Silicone · Code 0, joint torique (2-222) Supprimer le tri & les filtres
Référenceicon Dimension de pores (µm)icon Longueur nominale de la cartouche [in (cm)]icon
CGEP01TP30,210 (25) Prix & Disponibilité
CGEP02TP30,220 (50) Prix & Disponibilité
CGEP03TP30,230 (75) Prix & Disponibilité

Conditionnées à raison de 3 par boîte.

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Cartouches avec joints toriques en Silicone · Code 7, joints toriques (2-226) avec baïonnettes et embout à ailettes Supprimer le tri & les filtres
Référenceicon Dimension de pores (µm)icon Longueur nominale de la cartouche [in (cm)]icon
CGEP71TP30,210 (25) Prix & Disponibilité
CGEP72TP30,220 (50) Prix & Disponibilité
CGEP73TP30,230 (75) Prix & Disponibilité
CGEP75TP30,25 (12,5) Prix & Disponibilité

Conditionnées à raison de 3 par boîte
Les cartouches Code 7 de 10" existent en conditionnement à l'unité pour les études de validation. Pour obtenir la référence, veuillez remplacer le dernier chiffre par 1.

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Cartouches avec joints toriques en EPDM · Code 0, joint torique (2-222) Supprimer le tri & les filtres
Référenceicon Dimension de pores (µm)icon Longueur nominale de la cartouche [in (cm)]icon
CGEP01TE30,210 (25) Prix & Disponibilité
CGEP02TE30,220 (50) Prix & Disponibilité
CGEP03TE30,230 (75) Prix & Disponibilité

Conditionnées à raison de 3 par boîte.

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Cartouches avec joints toriques en EPDM · Code 7, joints toriques (2-226) avec baïonnettes et embout à ailettes Supprimer le tri & les filtres
Référenceicon Dimension de pores (µm)icon Longueur nominale de la cartouche [in (cm)]icon
CGEP71TE30,210 (25) Prix & Disponibilité
CGEP72TE30,220 (50) Prix & Disponibilité
CGEP73TE30,230 (75) Prix & Disponibilité
CGEP75TE30,25 (12,5) Prix & Disponibilité

Conditionnées à raison de 3 par boîte
Les cartouches Code 7 de 10" existent en conditionnement à l'unité pour les études de validation. Pour obtenir la référence, veuillez remplacer le dernier chiffre par 1.

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Cartouches avec joints toriques en Fluorocarbone · Code 0, joint torique (2-222) Supprimer le tri & les filtres
Référenceicon Dimension de pores (µm)icon Longueur nominale de la cartouche [in (cm)]icon
CGEP01TF30,210 (25) Prix & Disponibilité
CGEP02TF30,220 (50) Prix & Disponibilité
CGEP03TF30,230 (75) Prix & Disponibilité

Conditionnées à raison de 3 par boîte.

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Cartouches avec joints toriques en Fluorocarbone · Code 7, joints toriques (2-226) avec baïonnettes et embout à ailettes Supprimer le tri & les filtres
Référenceicon Dimension de pores (µm)icon Longueur nominale de la cartouche [in (cm)]icon
CGEP71TF30,210 (25) Prix & Disponibilité
CGEP72TF30,220 (50) Prix & Disponibilité
CGEP73TF30,230 (75) Prix & Disponibilité
CGEP75TF30,25 (12,5) Prix & Disponibilité

Conditionnées à raison de 3 par boîte
Les cartouches Code 7 de 10" existent en conditionnement à l'unité pour les études de validation. Pour obtenir la référence, veuillez remplacer le dernier chiffre par 1.

Retourner en haut de la page

    Documentation

    Brochure

    Titre
    OptiScale: a small scale screening tool for every application
    Opticap XL and XLT Capsules Configuration Table
    Reprint: Sterile Filtration of Ophthalmic Solutions

    Informations techniques

    Titre
    1X PBS (Phosphate Buffered Saline) Buffer Mixing Optimization
    Cellvento™ CHO-100 Media Mix and Filtration Optimization
    LVP Application Performance of Millipore Express SHC and SHF 0.2 μm Membranes
    Steam-in-Place Method in the Reverse Direction for Millipore Express PES Filters
    Sterile Filtration of Ophthalmic Solutions
    Sterile Filtration of Serum-free Mammalian Cell Culture Media
    The Vmax Nomograph Reference tool for Filter Sizing

    Posters

    Titre
    Quality by Design (QbD) Principles in Aseptic Processing

    Références bibliographiques

    Aperçu de la référence bibliographique
    "Schneller und effizienter" (Faster and more efficient)
    Ulrich Hoebel, Key Account Manager for Boehringer Ingelheim & Regional Sales Manager in Central Area
    Biotechnica Today, official journal of the Hannover tradeshow Biotechnica, published by the German magazine Laborpraxis, issue October 18 2005, page 9 2005

    Filtración esterilizante rápida y económica: tecnologia de membrana Express® (Faster Sterile Filtration with New Membrane Technology)
    Josep Vilella, Bioprocess Marketing, Tech Service and internal Support Specialist in Spain
    Tecnicas de Laboratorio (Spanish magazine), issue 306, November 2005 , page 975 2005

    Increasing the Speed of Buffer Filtration; Tutorial: Millipore Express SHF Filters Utilize Composite Asymmetric Polyethersulfone Sterile Membrane
    Laurelle Sciola-Tulecke and Susan Barrett
    GEN, Volume 23, Number 14, August 2003 2003

    FAQ

    QuestionRéponse
    What is the recommended procedure for running a pre-use integrity test? Millipore recommends sterilizing the filter prior to conducting a pre-use integrity test. (Ref. Steam-in-Place Method for Millipore Express SHF Filters Technical Brief, Lit#TB2000EN00) See also Millipore Express SHF integrity test recommendations.
    What is the recommended procedure if I get a failing integrity test value? Rewet according to the SHF insert, using up to 45 psig backpressure, and retest the cartridge using either an air/water diffusion test or an enhanced bubble point test; consisting of a diffusion test followed by a bubble point test.
    What is the recommended procedure for storing Millipore Express SHF filters (pre-use)? Per the Millipore Express SHF Wetting and Integrity Testing, Package Insert (P88057): “Filter Storage Conditions: Store filters at room temperature in their original packaging and away from direct sunlight. Do not remove filter from its bag until ready to use.”
    What is the recommended procedure for returning Millipore Express SHF filters (post use)? Return filters to original packaging materials and contact Technical Services for further details.
    What Millipore Express SHF configurations are currently available? Hydrophilic Millipore Express SHF 0.2 µm filters are currently available in 10-inch, 20-inch and 30-inch Code 0 & Code 7 cartridges, and in OptiScale capsules and 47 mm discs.
    Catalog No.Description
    CGEP71TP3Millipore Express SHF 0.2 10-inch CD7
    CGEP72TP3Millipore Express SHF 0.2 20-inch CD7
    CGEP73TP3Millipore Express SHF 0.2 30-inch CD7
    CGEP01TP3Millipore Express SHF 0.2 10-inch CD0
    CGEP02TP3Millipore Express SHF 0.2 20-inch CD0
    CGEP03TP3Millipore Express SHF 0.2 30-inch CD0
    SGEPA47FH3Millipore Express SHF OptiScale 47 mm 0.2 µm FH 3/PK
    SGEPA47FF3Millipore Express SHF OptiScale 47 mm 0.2 µm FF 3/PK
    SGEPA47HH3Millipore Express SHF OptiScale 47 mm 0.2 µm HH 3/PK
    GEPP04725Millipore Express SHF 0.2 Hydrophilic 47 mm Discs 25/PK
    Is the Millipore Express PES technology platform new to Millipore? No. In 1992, Millipore was granted the first patent on the Express membrane. Millipore’s Life Science division introduced the first generation of the Express PES membrane in 1995. Since then, successive generations of the Express membrane using advanced technologies have been introduced; with the Express Plus (2002) and now the Express SHF (2003).

    Millipore Express SHF membrane is the next generation of the Millipore Express technology - enabling caustic compatible, high flow rate, process scale devices.
    How should I search for Millipore Express SHF on the Millipore web site? We recommend typing “Millipore Express SHF” or “Express SHF”, including the quotes, into the search field. This will search for the entire phrase, and will display more targeted results than simply searching for the word “Express”.
    What literature is available for the Millipore Express SHF?
    Millipore Express SHF LiteratureLit Ref No.
    Millipore Express SHF Data SheetDS1426EN00
    Steam-in-Place Technical BriefTB2000EN00
    Certificate of QualityP75499
    Wetting and Integrity Testing Package InsertP88057
    GEN Article: Increasing the Speed for Buffer Filtration, Aug 2003
    Validation Guide
    RP1020ENUS
    *VG1012EN00, *VG1009EN00

    * Contact Technical Service for Validation Guides.
    • For help in the U.S and Canada, call 1-800-MILLIPORE (1-800-645-5476).
    • Outside of the U.S. and Canada, call the Millipore office nearest you.
    Is Millipore Express SHF a sterilizing grade membrane? Yes. The Millipore Express SHF membrane meets ASTM requirements of quantitative retention of 107 CFU/cm2 Brevundimonas diminuta ATCC® 19146 per ASTM methodology. Millipore Express SHF has the same probability of producing a sterile effluent as Durapore. The retention standards (ASTM 838-83) and protocols (ASTM, HIMA methodology) that were used to validate Durapore membrane were used to validate Millipore Express SHF.
    Why do Millipore Express SHF filters have such high flux? Versus Durapore, the morphology of the Millipore Express SHF membrane is different - having been optimized to provide very high flow rates with clean intermediate streams, such as buffers, with complete assurance of sterility.
    How is Durapore membrane different than Millipore Express SHF? Durapore membrane is made from a different polymer (polyvinylidene fluoride (PVDF) versus the polyethersulfone membrane of Millipore Express SHF) and has a different pore structure. These give Millipore SHF a flow advantage.
    How is the Millipore Express SHF membrane different than the Millipore Express and Express Plus membranes used for Life Science filtration? Millipore Express SHF was designed specifically for pharmaceutical applications, as a sterilizing grade, high flux, and caustic compatible membrane for large scale devices.

    Millipore Express and Express Plus membranes were designed for sterile filtration of tissue culture media and are not compatible with caustics. Millipore Express and Espress Plus are available only in laboratory scale devices.
    Is the Millipore Express SHF filter difficult to wet? No, the membrane is very hydrophilic.
    What is the recommended wetting procedure for Millipore Express SHF cartridges? Per Millipore's standard wetting procedure:
    Wet the dry cartridge at 1 lpm/ft2 for 5 minutes. This flow rate corresponds to 5.8 lpm (1.5 gpm) for a 5.8 ft2 cartridge.

    It is also possible to wet the filter at a lower flow rate than recommended for a longer duration (i.e.; 3L/min for 10 minutes) and pass the integrity test.
    What is the recommended wetting procedure for Millipore Express SHF 47mm discs? The wetting procedure for Millipore Express SHF discs is the same procedure for wetting Durapore 47mm discs: Dip the 47 mm disk in water or buffer prior to inserting in the holder. Make sure there are no air bubbles present between the membrane and the support material.
    What is the recommended wetting procedure for Millipore Express SHF OptiScales? The wetting procedure for OptiScale with Millipore Express SHF is the same procedure for wetting OptiScale with Durapore: OptiScales are generally flushed with water, usually about 100 mls for a 47 mm disk.
    Are integrity tests are run on Millipore Express SHF cartridges prior to release? All Millipore Express SHF filters are 100% integrity tested prior to release.
    What is the recommended integrity test for Millipore Express SHF filters? The recommended integrity test for Millipore Express SHF filters is either an air/water diffusion test or an enhanced bubble point test; consisting of a diffusion test followed by a bubble point test.

    Note: If a product specific integrity testing is desired, contact ACCESS services for assistance.
    How do I integrity test this filter? For diffusion testing, cartridge integrity can be measured either: 1) .visually with a downstream mass flow monitor, or 2). with an inverted graduated cylinder, or 3). using an automated integrity tester. For bubble point testing, an enhanced bubble point test (diffusion test followed by a bubble point test) using an automated integrity tester is recommended.

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    Biopharmaceutical Manufacturing > Downstream Processing > Sterile Filtration > Sterile Liquid > Millipore Express > Millipore Express SHF