MAB4339 | Anti-REN-1 Antibody, clone 2G6.2

100 µg  
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      Tableau de caractéristiques principal

      Espèces réactives Principales applications Hôte Format Type d'anticorps
      R, SourisImmunocytochimie, ELISA, WBSourisPurifié(e) Anticorps monoclonal
      Référence MAB4339
      Famille de marques Chemicon®
      Nom de marque
      • Chemicon
      Description Anti-REN-1 Antibody, clone 2G6.2
      Informations générales REN is a developmentally regulated gene that promotes neural cell differentiation. REN expression is upregulated by embryonic stem cells, following induction by neurogenic signals. It may play a role in neural promotion and can serve as both a marker and regulator of neuronal differentiation.
      Références bibliographiques
      Informations produit
      Format Purifié(e)
      Présentation Liquid in PBS with 0.1% sodium azide
      Application Detect REN-1 using this Anti-REN-1 Antibody, clone 2G6.2 validated for use in ELISA, WB & IC.
      Principales applications
      • Immunocytochimie
      • ELISA
      • Western Blotting
      Informations biologiques
      Espèces d'immunogène Recombinant GST-Murine fusion protein, murine REN-1
      Clone 2G6.2
      Concentration Please refer to the Certificate of Analysis for the lot-specific concentration.
      Hôte Souris
      Isotype IgG2bκ
      Espèces réactives Rat Souris
      Type d'anticorps Anticorps monoclonal
      Code Entrez Gene
      Résumé Entrez Gene Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
      Symbole du gène
      • EC
      • REN
      • Angiotensinogenase
      • angiotensinogenase
      • renin
      • FLJ10761
      Code UniProt
      Résumé UniProt FUNCTION: SwissProt: P00797 # Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
      SIZE: 406 amino acids; 45057 Da
      SUBUNIT: Interacts with ATP6AP2.
      SUBCELLULAR LOCATION: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.
      DISEASE: SwissProt: P00797 # Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
      SIMILARITY: SwissProt: P00797 ## Belongs to the peptidase A1 family.
      Informations physico-chimiques
      Informations sur les matériaux
      Informations toxicologiques
      Informations de sécurité selon le SGH
      Informations sur la sécurité
      Notifications sur l'utilisation du produit
      Notification sur l'utilisation
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Informations relatives au stockage et à l'expédition
      Conditions de stockage Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Informations sur l'emballage
      Taille du matériau 100 µg
      Informations sur le transport
      Information complémentaire


      Certificats d'analyse

      TitreNuméro de lot
      REN-1 MONOCLONAL ANTIBODY - 2318793 2318793

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons.
      Shang-Der Chen,Chia-Lin Wu,Tsu-Kung Lin,Yao-Chung Chuang,Ding-I Yang
      Neurochemistry international 61 2012

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      Fiche technique

      Anti-REN-1, clone 2G6.2 - Data Sheet