GF030 | Glial Derived Neurotrophic Factor Protein, Recombinant human

GF030
10 µg  
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      Overview

      Replacement Information

      Tableau de caractéristiques principal

      Espèce Source Pureté
      HumanE.coliGreater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of human GDNF.
      Description
      Référence GF030
      Famille de marques Chemicon®
      Synonymes GDNF
      Nom de marque
      • Chemicon
      Description Glial Derived Neurotrophic Factor Protein, Recombinant human
      Aperçu Human Glial Derived Neurotrophic Factor (GDNF) is a 30.4 kDa protein that specifically promotes dopamine uptake and survival of midbrain neurons. GDNF is a disulphide linked homodimeric protein consisting of two 134 amino acid chains.
      Références bibliographiques
      Informations produit
      Présentation Lyophilized from 10 mM Sodium Citrate and 150 mM NaCl. Contains no preservative.
      Applications
      Application The human Glial Derived Neurotrophic Factor (GDNF) is a 30.4 kDa protein that specifically promotes dopamine uptake & survival of midbrain neurons.
      Informations biologiques
      Pureté Greater than 98% by SDS-PAGE and HPLC analysis. Endotoxin level is less than 0.1 ng per μg (1EU/ug) of human GDNF.
      Source E.coli
      Espèce Human
      Activité spécifique Chemicon's human GDNF is fully biologically active when compared to standards as determined by the dose-dependent dopamine uptake by rat ventral mesencephalic cultures. The ED(50) was found to be in the range of 5-10 ng/mL. <br />The ED(50) as determined by the proliferation of rat C6 cells is ≤ 0.1 ng/mL, corresponding to aspecific activity of ≥ 1 x 10<sup>7</sup> units/mg.
      Code Entrez Gene
      Résumé Entrez Gene This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.
      Symbole du gène
      • ATF
      • GDNF
      • HFB1-GDNF
      • ATF1
      • ATF2
      • hGDNF
      Code UniProt
      Résumé UniProt FUNCTION: SwissProt: P39905 # Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
      SIZE: 211 amino acids; 23720 Da
      SUBUNIT: Homodimer; disulfide-linked.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
      DISEASE: SwissProt: P39905 # Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. & Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
      SIMILARITY: SwissProt: P39905 ## Belongs to the TGF-beta family. GDNF subfamily.
      Informations physico-chimiques
      Dimensions
      Informations sur les matériaux
      Informations toxicologiques
      Informations de sécurité selon le SGH
      Informations sur la sécurité
      Notifications sur l'utilisation du produit
      Notification sur l'utilisation
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Informations relatives au stockage et à l'expédition
      Conditions de stockage The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. The lyophilized power can be reconstituted to 0.1-1.0 mg/mL. This solution can be diluted into water or other buffered solutions. Reconstituted GDNF should be stored in undiluted aliquots at -20°C for up to 6 months.
      Informations sur l'emballage
      Quantité 10 µg
      Informations sur le transport
      Information complémentaire
      Caractéristiques

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      Certificats d'analyse

      TitreNuméro de lot
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - 21159232115923
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - 21530012153001
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - 23874712387471
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - 24589972458997
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - 20021662002166
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - 23090302309030
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - 23250372325037
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - 24946132494613
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR -25124142512414
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR -25287642528764
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR -25671142567114
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR -25858592585859
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR -25869332586933

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Soluble factor effects on glial cell reactivity at the surface of gel-coated microwires.
      Vadim S Polikov,Jau-Shyong Hong,William M Reichert
      Journal of neuroscience methods 190 2010

      Afficher le résumé Article en texte intégral
      20470825
      Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits.
      Nathaniel A Sowa,Bonnie Taylor-Blake,Mark J Zylka
      The Journal of neuroscience : the official journal of the Society for Neuroscience 30 2010

      Afficher le résumé Article en texte intégral
      20147550

      Fiche technique

      Titre
      RECOMBINANT HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR - Data Sheet

      Produits & Applications associés

      Familles de produits

      Catégories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors