AB15102 | Anti-Mint-1 Antibody

AB15102
100 µL  
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      Overview

      Replacement Information

      Offres spéciales

      Tableau de caractéristiques principal

      Espèces réactives Principales applications Hôte Format Type d'anticorps
      RWBLapinSérumAnticorps polyclonal
      Description
      Référence AB15102
      Famille de marques Chemicon®
      Nom de marque
      • Chemicon
      Description Anti-Mint-1 Antibody
      Références bibliographiques
      Informations produit
      Format Sérum
      Présentation Liquid
      Applications
      Application Detect Mint-1 using this Anti-Mint-1 Antibody validated for use in WB.
      Principales applications
      • Western Blotting
      Notes opératoires Western blot: 1:5,000-1:10,000 using ECL (5 min exposure)
      Optimal working dilutions must be determined by the end user.
      Informations biologiques
      Espèces d'immunogène Synthetic peptide from rat.
      Hôte Lapin
      Spécificité Mint-1. By Western blot the antibody recognizes a band at ~130 kDa in rat brain lysate.
      Espèces réactives Rat
      Type d'anticorps Anticorps polyclonal
      Code Entrez Gene
      Résumé Entrez Gene The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
      Symbole du gène
      • MINT1
      • APBA1
      • D9S411E
      • X11
      • X11A
      • X11ALPHA
      Méthode de purification Serum
      Code UniProt
      Résumé UniProt FUNCTION: SwissProt: Q02410 # Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.
      SIZE: 837 amino acids; 92865 Da
      SUBUNIT: Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP).
      TISSUE SPECIFICITY: Brain and spinal cord.
      DOMAIN: SwissProt: Q02410 Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
      SIMILARITY: Contains 2 PDZ (DHR) domains. & Contains 1 PID domain.
      Informations physico-chimiques
      Dimensions
      Informations sur les matériaux
      Informations toxicologiques
      Informations de sécurité selon le SGH
      Informations sur la sécurité
      Notifications sur l'utilisation du produit
      Notification sur l'utilisation
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Informations relatives au stockage et à l'expédition
      Conditions de stockage Maintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Informations sur l'emballage
      Quantité 100 µL
      Informations sur le transport
      Information complémentaire
      Caractéristiques