05-587 | Anti-phospho-Adducin (Ser724) Antibody, clone pADD

WB: Non-stimulated (lane 1) and PMA-stimulated (lane 2) human red blood cell lysate, was probed with anti-phospho-Adducin, clone pADD (S724) (0.5μg/ml).
WB: Non-stimulated (lane 1) and PMA-stimulated (lane 2) human red blood cell lysate, was probed with
05-587
100 µg  
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      Overview

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      Tableau de caractéristiques principal

      Espèces réactives Principales applications Hôte Format Type d'anticorps
      R, Humain, SourisImmunocytochimie, Immunoprécipitation, WBSourisPurifié(e) Anticorps monoclonal
      Description
      Référence 05-587
      Famille de marques Upstate
      Nom de marque
      • Upstate
      Description Anti-phospho-Adducin (Ser724) Antibody, clone pADD
      Références bibliographiques
      Informations produit
      Format Purifié(e)
      Présentation 0.7M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.
      Applications
      Application Detect phospho-Adducin (Ser724) using this Anti-phospho-Adducin (Ser724) Antibody, clone pADD validated for use in IP, WB & IC.
      Principales applications
      • Immunocytochimie
      • Immunoprécipitation
      • Western Blotting
      Informations biologiques
      Espèces d'immunogène peptide (FRTP[pS]FLKK) corresponding to amino acids 720-728 of rat phospho-α-Adducin (Ser724)
      Clone pADD
      Hôte Souris
      Spécificité phospho-Adducin isoforms
      Isotype IgG
      Espèces réactives Rat Humain Souris
      Type d'anticorps Anticorps monoclonal
      Code Entrez Gene
      Résumé Entrez Gene Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
      Symbole du gène
      • MGC3339
      • ADD1
      • ADDA
      • Alpha-adducin
      • MGC44427
      Modifications
      • Phosphorylation
      Méthode de purification Protein G chromatography
      Code UniProt
      Résumé UniProt FUNCTION: SwissProt: P35611 # Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
      SIZE: 737 amino acids; 80955 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit. Binds ROCK1.
      SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
      TISSUE SPECIFICITY: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
      DOMAIN: SwissProt: P35611 Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
      PTM: The N-terminus is blocked.
      SIMILARITY: Belongs to the aldolase class II family. Adducin subfamily.
      Informations physico-chimiques
      Dimensions
      Informations sur les matériaux
      Informations toxicologiques
      Informations de sécurité selon le SGH
      Informations sur la sécurité
      Notifications sur l'utilisation du produit
      Assurance Qualité routinely evaluated by immunoblot on lysates from human red blood cells stimulated with PMA
      Notification sur l'utilisation
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Informations relatives au stockage et à l'expédition
      Conditions de stockage 2 years at -20°C
      Informations sur l'emballage
      Quantité 100 µg
      Informations sur le transport
      Information complémentaire
      Caractéristiques

      Documentation

      Certificats d'analyse

      TitreNuméro de lot
      Anti-phospho-Adducin (Ser724), clone pADD - 2019920199
      Anti-phospho-Adducin (Ser724), clone pADD - 2768827688

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Src protein-tyrosine kinase structure and regulation.
      Roskoski, Robert
      Biochem. Biophys. Res. Commun., 324: 1155-64 (2004) 2004

      Afficher le résumé
      15504335
      Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis
      Silva, Corinne M
      Oncogene, 23:8017-23 (2004) 2004

      15489919