573099 | STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem

573099
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      Overview

      Replacement Information

      Tabla espec. clave

      Fórmula empírica Nº CAS
      C₈H₅NO₄S19983-44-9

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      573099-25MG
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          25 mg
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          Descripción
          Visión de conjunto A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
          Número de catálogo 573099
          Marca de familia Calbiochem®
          Sinónimos 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
          Referencias bibliográficas
          Referencias bibliográficas Schust, J., et al. 2006. Chem. Biol. 13, 1235.
          Información del producto
          Número de CAS 19983-44-9
          ATP Competitivo N
          Formulario Pale yellow solid
          Fórmula Hill C₈H₅NO₄S
          Fórmula química C₈H₅NO₄S
          Molar Mass 211.2
          Reversible N
          Imagen fórmula estructural
          Aplicaciones
          Información biológica
          Objetivo principal STAT3
          Pureza ≥95% by HPLC
          Información fisicoquímica
          Permeabilidad celular Y
          Solubilidad DMSO or EtOH
          Dimensiones
          Información de materiales
          Información toxicológica
          Información de seguridad según el GHS
          Información de seguridad
          Declaraciones de uso del producto
          Información de almacenamiento y transporte
          Código de envío Ambient Temperature Only
          Toxicidad Irritant
          Almacenamiento +2°C to +8°C
          Proteger de la luz Protect from light
          No congelar No
          Instrucciones especiales Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
          Información sobre embalaje
          Envasado en atmósfera inerte Packaged under inert gas
          Información de transporte
          Información complementaria
          Especificaciones

          Documentation

          Ficha datos de seguridad (MSDS)

          Idiomas
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          Ellas English España
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          България

          Certificados de análisis

          CargoNúmero de lote
          573099

          Referencias bibliográficas

          Visión general referencias
          Schust, J., et al. 2006. Chem. Biol. 13, 1235.

          Licencias necesarias e Información técnica

          Cargo
          JAK/STAT Signaling Research Focus
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revisión 22-June-2007 JSW
          Sinónimos 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
          Descripción A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
          Formulario Pale yellow solid
          Gas inerte (Sí/No) Packaged under inert gas
          Número de CAS 19983-44-9
          Masa molar 211.2
          Fórmula química C₈H₅NO₄S
          Fórmula estructural
          Pureza ≥95% by HPLC
          Solubilidad DMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Almacenamiento +2°C to +8°C
          Protect from light
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
          Toxicidad Irritant
          Referencias bibliográficas Schust, J., et al. 2006. Chem. Biol. 13, 1235.