371715 | Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem

371715
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      Overview

      Replacement Information

      Tabla espec. clave

      Fórmula empírica Nº CAS
      C₁₃H₁₄N₂O₄S₂67-99-2

      Precios y disponibilidad

      Número de referenciaDisponiblidad Embalaje Cant./Env. Precio Cantidad
      371715-1MG
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          1 mg
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          Descripción
          Visión de conjunto An immunosuppressive secondary metabolite produced by several pathogenic fungi. Immunosuppressive effects are caused by blocking of membrane thiol groups. Causes apoptotic cell death in a variety of cell types including macrophages and thymocytes. Farnesyltransferase (FTase) inhibitor (IC50 = 1.1 µM). Reported to increase ryanodine Ca2+ channel activity possibly by oxidizing cysteine residues located on the ryanodine receptor. Specifically inhibits NF-κB activation in B and T cells at nanomolar concentrations.
          Número de catálogo 371715
          Marca de familia Calbiochem®
          Sinónimos 2,3,5a,6-Tetrahydro-6-hydroxy-3(hyroxymethyl)-2-methyl-10H-3a,10a-epidithio-pyrazinol[1,2α]indole-1,4-dione
          Referencias bibliográficas
          Referencias bibliográficas Green, D., et al. 2000. J. Membr. Biol. 175, 223.
          Sutton, P., et al. 1995. Transplantation 60, 900.
          Waring, P., et al. 1995. Biochem. Pharmacol. 49, 1195.
          Waring, P., and Sjaarda, A. 1995. Int. J. Immunopharmacol. 17, 403.
          Van der Pyl, D., et al. 1992. J. Antibiot. 45, 1802.
          Jones, R.J., and Hancock, J.G. 1988. J. Gen. Microbiol. 134, 2067.
          Waring, P., et al. 1988. J. Biol. Chem. 263, 18493.
          Información del producto
          Número de CAS 67-99-2
          ATP Competitivo N
          Formulario White solid
          Fórmula Hill C₁₃H₁₄N₂O₄S₂
          Fórmula química C₁₃H₁₄N₂O₄S₂
          Molar Mass 326.4
          Reversible N
          Imagen fórmula estructural
          Aplicaciones
          Información biológica
          Objetivo principal FTase
          Objetivo principal IC50 1.1 µM against Farnesyltransferase (FTase)
          Pureza ≥98% by TLC
          Información fisicoquímica
          Permeabilidad celular N
          Solubilidad DMSO or EtOH
          Dimensiones
          Información de materiales
          Información toxicológica
          Información de seguridad según el GHS
          RTECS KB4725000
          Información de seguridad
          Frase R R: 23/24/25

          Frase S S: 36/37/39-45


          Declaraciones de uso del producto
          Información de almacenamiento y transporte
          Código de envío Ambient Temperature Only
          Toxicidad Toxic
          Advertencia de materiales peligrosos: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Almacenamiento +2°C to +8°C
          No congelar No
          Instrucciones especiales Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Información sobre embalaje
          Información de transporte
          Información complementaria
          Especificaciones

          Documentation

          Ficha datos de seguridad (MSDS)

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          Certificados de análisis

          CargoNúmero de lote
          371715

          Referencias bibliográficas

          Visión general referencias
          Green, D., et al. 2000. J. Membr. Biol. 175, 223.
          Sutton, P., et al. 1995. Transplantation 60, 900.
          Waring, P., et al. 1995. Biochem. Pharmacol. 49, 1195.
          Waring, P., and Sjaarda, A. 1995. Int. J. Immunopharmacol. 17, 403.
          Van der Pyl, D., et al. 1992. J. Antibiot. 45, 1802.
          Jones, R.J., and Hancock, J.G. 1988. J. Gen. Microbiol. 134, 2067.
          Waring, P., et al. 1988. J. Biol. Chem. 263, 18493.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revisión 12-May-2008 RFH
          Sinónimos 2,3,5a,6-Tetrahydro-6-hydroxy-3(hyroxymethyl)-2-methyl-10H-3a,10a-epidithio-pyrazinol[1,2α]indole-1,4-dione
          Descripción An immunosuppressive mycotoxin secondary metabolite produced by several pathogenic fungi. Reported to increase ryanodine Ca2+ channel activity possibly by oxidizing cysteine residues located on the ryanodine receptor. Immunosuppressive effect is caused by the blocking of membrane thiol groups. Causes apoptosis in a variety of cell types, including macrophages and thymocytes. Inactivates alcohol dehydrogenase by either covalent modification of thiol groups or free radical damage. Protein farnesyltransferase (PFT) inhibitor (IC50 = 1.1 µM). Also inhibits Ras protein in a noncompetitive manner.
          Formulario White solid
          Número de CAS 67-99-2
          RTECS KB4725000
          Masa molar 326.4
          Fórmula química C₁₃H₁₄N₂O₄S₂
          Fórmula estructural
          Pureza ≥98% by TLC
          Solubilidad DMSO (10 mg/ml) or Ethanol (2 mg/ml)
          Almacenamiento +2°C to +8°C
          Do Not Freeze No
          Special Instructions Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicidad Toxic
          Índice Merck EE.UU. 14, 4441
          Referencias bibliográficas Green, D., et al. 2000. J. Membr. Biol. 175, 223.
          Sutton, P., et al. 1995. Transplantation 60, 900.
          Waring, P., et al. 1995. Biochem. Pharmacol. 49, 1195.
          Waring, P., and Sjaarda, A. 1995. Int. J. Immunopharmacol. 17, 403.
          Van der Pyl, D., et al. 1992. J. Antibiot. 45, 1802.
          Jones, R.J., and Hancock, J.G. 1988. J. Gen. Microbiol. 134, 2067.
          Waring, P., et al. 1988. J. Biol. Chem. 263, 18493.