PI-12K | Porcine Insulin RIA

PI-12K
250 tubes  
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      Overview

      Replacement Information

      Tabla espec. clave

      Analitos disponibles Reactividad según especies Aplicaciones clave Métodos de detección
      InsulinCerdoRadioinmunoensayo125I, Radioactivo
      Descripción
      Número de catálogo PI-12K
      Descripción Porcine Insulin RIA
      Información preliminar Insulin is a 5.8 kD hormone is secreted by the islet cells in the pancreas.
      Referencias bibliográficas
      Información del producto
      Método de detección 125I Radioactivo
      Especificidad Porcine Insulin 100% Procine Proinsulin 53% Human Insulin 100% Bovine Insulin 90% Bovine Proinsulin 50% Intact Human Proinsulin 38% Rat Insulin 19% Des 31, 32 HPI 47% Des 64, 65 HPI 72% Glucagon Not Detectable Pancreatic Polypeptide Not Detectable Somatos
      Rendimiento
      • ED20 = 126 ± 3.0 µU/ml
      • ED80 = 7 ± 0.6 µU/ml
      • ED50 = 30 ± 1.2 µU/ml
      Aplicaciones
      Aplicación This radioimmunoassay (RIA) measures & quantifies Insulin for use in Metabolism & Endocrine research.
      Aplicaciones clave
      • Radioinmunoensayo
      Notas de aplicación Overnight, equilibrium incubation at 4°C. Sample volume < 100 μl serum, plasma, or tissue culture media.
      Información biológica
      Especificidad Porcine Insulin 100% Procine Proinsulin 53% Human Insulin 100% Bovine Insulin 90% Bovine Proinsulin 50% Intact Human Proinsulin 38% Rat Insulin 19% Des 31, 32 HPI 47% Des 64, 65 HPI 72% Glucagon Not Detectable Pancreatic Polypeptide Not Detectable Somatos
      Reactividad según especies Cerdo
      Analitos disponibles
      • Insulin
      Resumen de Entrez Gene After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
      Etiqueta 125I-Insulin
      Número UniProt
      Resumen UniProt FUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Información fisicoquímica
      Intervalo de curvas patrón
      • 2–200 µU/mL
      Dimensiones
      Información de materiales
      Información toxicológica
      Información de seguridad según el GHS
      Información de seguridad
      Declaraciones de uso del producto
      Declaración de uso
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Información de almacenamiento y transporte
      Información sobre embalaje
      Cantitad 250 tubes
      Información de transporte
      Información complementaria
      Especificaciones

      Documentation

      Protocols

      Title
      PORCINE INSULIN RIA KIT - 250 TUBES (Cat. # PI-12K)

      Ficha datos de seguridad (MSDS)

      Idiomas
      English

      Referencias bibliográficas | 11 Disponible | Ver todas las referencias

      Visión general referenciasPub Med ID
      Cereal type and heat processing of the cereal affect nutrient digestibility and dynamics of serum insulin and ghrelin in weanling pigs.
      Menoyo D, Serrano MP, Barrios V, Valencia DG, Lázaro R, Argente J, Mateos GG
      Journal of animal science 2011

      Mostrar resumen
      21478449
      Gene expression profiling of the short-term adaptive response to acute caloric restriction in liver and adipose tissues of pigs differing in feed efficiency.
      Lkhagvadorj S, Qu L, Cai W, Couture OP, Barb CR, Hausman GJ, Nettleton D, Anderson LL, Dekkers JC, Tuggle CK
      American journal of physiology. Regulatory, integrative and 298 R494-R507 2010

      Mostrar resumen
      19939971
      Postprandial response of plasma insulin, amylin and acylated ghrelin to various test meals in lean and obese cats.
      Martin LJ, Siliart B, Lutz TA, Biourge V, Nguyen P, Dumon HJ
      The British journal of nutrition 2010

      Mostrar resumen
      20100379
      Performance and metabolic and endocrine changes with emphasis on glucose metabolism in high-yielding dairy cows with high and low fat content in liver after calving.
      H M Hammon, G Stürmer, F Schneider, A Tuchscherer, H Blum, T Engelhard, A Genzel, R Staufenbiel, W Kanitz
      Journal of dairy science 92 1554-66 2009

      Mostrar resumen
      19307636
      Metabolic changes and net portal flux in dairy cows fed a ration containing rumen-protected fat as compared to a control diet.
      H M Hammon,C C Metges,P Junghans,F Becker,O Bellmann,F Schneider,G Nürnberg,P Dubreuil,H Lapierre
      Journal of dairy science 91 2008

      Mostrar resumen
      18096942
      Acute metabolic responses of postpartal dairy cows to subcutaneous glucagon injections, oral glycerol, or both.
      M A Osman, P S Allen, N A Mehyar, G Bobe, J F Coetzee, K J Koehler, D C Beitz
      Journal of dairy science 91 3311-22 2008

      Mostrar resumen
      18765590
      Induction of hyperlipidemia by intravenous infusion of tallow emulsion causes insulin resistance in Holstein cows.
      J A A Pires, A H Souza, R R Grummer
      Journal of dairy science 90 2735-44 2007

      Mostrar resumen
      17517713
      Gonadectomy and high dietary fat but not high dietary carbohydrate induce gains in body weight and fat of domestic cats.
      Robert C Backus, Nick J Cave, Duane H Keisler
      The British journal of nutrition 98 641-50 2007

      Mostrar resumen
      17524182
      Glucose-dependent insulin response and milk production in heifers within a segregating resource family population.
      H M Hammon, O Bellmann, J Voigt, F Schneider, C Kühn
      Journal of dairy science 90 3247-54 2007

      Mostrar resumen
      17582108
      Comparing mRNA levels of genes encoding leptin, leptin receptor, and lipoprotein lipase between dairy and beef cattle.
      M Q Ren, J Wegner, O Bellmann, G A Brockmann, F Schneider, F Teuscher, K Ender
      Domestic animal endocrinology 23 371-81 2002

      Mostrar resumen
      12206871

      Folleto

      Cargo
      Immunoassay & Multiplex Kits: Analyte Quarterly, Volume 3, 2014

      Ficha técnica

      Cargo
      Full Service Custom-built Assays