AB3421 | Anti-Complement C3 Antibody

AB3421
100 µg  
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      Overview

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Reactividad según especies Aplicaciones clave Hospedador Formato Tipo de anticuerpo
      Ser humanoELISAPolloPurificado por afinidadAnticuerpo policlonal
      Descripción
      Número de catálogo AB3421
      Marca de familia Chemicon®
      Nombre comercial
      • Chemicon
      Descripción Anti-Complement C3 Antibody
      Referencias bibliográficas
      Información del producto
      Formato Purificado por afinidad
      Presentación Chicken IgY fraction, in 0.15 M NaCl, 0.02 M NaH2PO4, 0.1% NaN3, pH 7.2.
      Aplicaciones
      Aplicación Detect Complement C3 using this Anti-Complement C3 Antibody validated for use in ELISA.
      Aplicaciones clave
      • ELISA
      Notas de aplicación ELISA, direct: 0.1 μg/mL

      It is expected that the antibody will also work for Western blot, immunohistochemistry and immunocytochemistry. Specific reactivity has not been confirmed.

      Optimal working dilutions must be determined by the end user.
      Información biológica
      Especies inmunógenas Human C3, full length plasma protein.
      Concentración Please refer to the Certificate of Analysis for the lot-specific concentration.
      Hospedador Pollo
      Especificidad Complement C3
      Reactividad según especies Ser humano
      Tipo de anticuerpo Anticuerpo policlonal
      Número de Entrez Gene
      Resumen de Entrez Gene Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptable to bacteria infection.
      Símbolo de gen
      • CPAMD1
      • C3
      • ASP
      • ARMD9
      Número UniProt
      Resumen UniProt FUNCTION: SwissProt: P01024 # Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
      SIZE: 1663 amino acids; 187148 Da
      SUBUNIT: C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with CR2 and VSIG4.
      SUBCELLULAR LOCATION: Secreted.
      PTM: C3b is rapidly split in two positions by factor I and a cofactor to form iC3b (inactivated C3b) and C3f which is released. Then iC3b is slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f. Other proteases produce other fragments such as C3d or C3g.
      DISEASE: SwissProt: P01024 # Defects in C3 are the cause of C3 deficiency [MIM:120700]. It can result in susceptibility to pyogenic infection. & Genetic variation in C3 is associated with susceptibility to age-related macular degeneration type 9 (ARMD9) [MIM:611378]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
      SIMILARITY: SwissProt: P01024 ## Contains 1 anaphylatoxin-like domain. & Contains 1 NTR domain.
      Información fisicoquímica
      Dimensiones
      Información de materiales
      Información toxicológica
      Información de seguridad según el GHS
      Información de seguridad
      Declaraciones de uso del producto
      Declaración de uso
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Información de almacenamiento y transporte
      Condiciones de almacenamiento Maintain at 2-8*C in undiluted aliquots up to 6 months after date of receipt.
      Avoid freezing temperatures.
      Información sobre embalaje
      Cantitad 100 µg
      Información de transporte
      Información complementaria
      Especificaciones

      Documentation

      Certificados de análisis

      CargoNúmero de lote
      CHICKEN ANTI-COMPLEMENT C3 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 24396462439646
      CHICKEN ANTI-COMPLEMENT C3 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 23435432343543
      CHICKEN ANTI-COMPLEMENT C3 -25505752550575
      CHICKEN ANTI-COMPLEMENT C3 -25795072579507

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Complement interaction with trypanosomatid promastigotes in normal human serum.
      Domínguez, Mercedes, et al.
      J. Exp. Med., 195: 451-9 (2002) 2002

      Mostrar resumen
      11854358

      Ficha técnica

      Cargo
      CHICKEN ANTI-COMPLEMENT C3