AB10615 | Anti-PDEF Antibody

AB10615
100 µg  
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      Overview

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Reactividad según especies Aplicaciones clave Hospedador Formato Tipo de anticuerpo
      Ser humanoWB, ELISAConejoPurificado por afinidadAnticuerpo policlonal
      Descripción
      Número de catálogo AB10615
      Marca de familia Chemicon®
      Nombre comercial
      • Chemicon
      Descripción Anti-PDEF Antibody
      Alternate Names
      • Prostate-derived Ets Factor
      Información preliminar PDEF (prostate-derived Ets factor) is a 37.5-kDa protein that acts as an androgen-independent transcriptional activator for the PSA (prostate specific antigen) promoter. It also interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter. PDEF was shown to have transcript levels 192-fold higher in the peripheral blood of some breast cancer patients in comparison with normal individuals. PDEF mRNA is also frequently over-expressed in human breast tumors as well as in human ovarian tumors. In ovarian tumors, PDEF expression seems to down-modulate malignant potential, and thus provides a rationale to screen for drugs that induce PDEF expression in epithelial ovarian tumors.
      Referencias bibliográficas
      Información del producto
      Formato Purificado por afinidad
      Presentación This polyclonal antibody is supplied in 400 μL of phosphate buffered saline (pH 7.4) containing 0.1% sodium azide.
      Aplicaciones
      Aplicación Detect PDEF using this Anti-PDEF Antibody validated for use in ELISA & WB.
      Aplicaciones clave
      • Western Blotting
      • ELISA
      Notas de aplicación ELISA: 0.1-1μg/mL
      Western Blotting: 1-3 μg/mL
      Información biológica
      Especies inmunógenas Synthetic peptide derived from the internal region of human PDEF (prostate-derived Ets factor).
      Concentración Please refer to the Certificate of Analysis for the lot-specific concentration.
      Hospedador Conejo
      Especificidad Recognizes PDEF.
      Reactividad según especies Ser humano
      Species Reactivity Note Human (positive control: LNCaP cells)
      Tipo de anticuerpo Anticuerpo policlonal
      Número de Entrez Gene
      Resumen de Entrez Gene PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]
      Símbolo de gen
      • RP11-375E1__A.3
      • SPDEF
      • bA375E1.3
      • PSE
      • PDEF
      Método de purificación Immunoaffinity purified
      Número UniProt
      Resumen UniProt FUNCTION: SwissProt: O95238 # May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
      SIZE: 335 amino acids; 37518 Da
      SUBUNIT: Interacts with the DNA-binding domain of the androgen receptor. Interacts with NKX3-1.
      SUBCELLULAR LOCATION: Nucleus (Probable).
      TISSUE SPECIFICITY: Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells.
      SIMILARITY: SwissProt: O95238 ## Belongs to the ETS family. & Contains 1 ETS DNA-binding domain. & Contains 1 PNT (pointed) domain.
      Información fisicoquímica
      Dimensiones
      Información de materiales
      Información toxicológica
      Información de seguridad según el GHS
      Información de seguridad
      Declaraciones de uso del producto
      Declaración de uso
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Información de almacenamiento y transporte
      Condiciones de almacenamiento Store at -20°C in undiluted aliquots for 1 year from date of shipment.
      Información sobre embalaje
      Cantitad 100 µg
      Información de transporte
      Información complementaria
      Especificaciones

      Documentation

      Ficha datos de seguridad (MSDS)

      Idiomas
      Deutschland English

      Certificados de análisis

      CargoNúmero de lote
      RABBIT ANTI-PDEF POLYCLONAL ANTIBODY - 20021762002176

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Prostate epithelium-derived Ets transcription factor mRNA is overexpressed in human breast tumors and is a candidate breast tumor marker and a breast tumor antigen.
      Ghadersohi, A and Sood, A K
      Clin. Cancer Res., 7: 2731-8 (2001) 2001

      Mostrar resumen
      11555586
      PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.
      Oettgen, P, et al.
      J. Biol. Chem., 275: 1216-25 (2000) 2000

      Mostrar resumen
      10625666

      Ficha técnica

      Cargo
      Anti-PDEF - Data Sheet