06-676 | Anti-mGluR2/3 Antibody

WB: Rat brain microsome extract probed with anti-mGluR2/3 at 0.5μg/ml
06-676
200 µg  
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      Overview

      Ofertas especiales

      Tabla espec. clave

      Reactividad según especiesAplicaciones claveHospedadorFormatoTipo de anticuerpo
      Rata, RatónWB, Inmunohistoquímica, InmunoprecipitaciónConejoPurificadoAnticuerpo policlonal
      Descripción
      Número de catálogo 06-676
      Marca de familia Upstate
      Nombre comercial
      • Upstate
      Descripción Anti-mGluR2/3 Antibody
      Referencias bibliográficas
      Información del producto
      Formato Purificado
      Especificidad mGluR2 and mGluR3
      Presentación 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol
      Aplicaciones
      Aplicación Anti-mGluR2/3 Antibody is an antibody against mGluR2/3 for use in IH, IP & WB.
      Aplicaciones clave
      • Western Blotting
      • Inmunohistoquímica
      • Inmunoprecipitación
      Información biológica
      Especies inmunógenas peptide (KQFVPTVCNGREVVDSTTSSL) corresponding to amino acids 853-872 of human metabotropic glutamate receptor 2
      Hospedador Conejo
      Especificidad mGluR2 and mGluR3
      Isotipo IgG
      Reactividad según especies Rata Ratón
      Tipo de anticuerpo Anticuerpo policlonal
      Número de Entrez Gene
      Resumen de Entrez Gene L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
      Símbolo de gen
      • mGluR2
      • GRM2
      • GPRC1B
      • MGLUR2
      • GLUR2
      • mGlu2
      Método de purificación Protein A chromatography
      Número UniProt
      Resumen UniProt FUNCTION: SwissProt: Q14416 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
      SIZE: 872 amino acids; 95568 Da
      SUBUNIT: Interacts with GRASP (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain.
      SIMILARITY: SwissProt: Q14416 ## Belongs to the G-protein coupled receptor 3 family.
      Información fisicoquímica
      Dimensiones
      Información de materiales
      Información toxicológica
      Información de seguridad según el GHS
      Información de seguridad
      Declaraciones de uso del producto
      Aseguramiento de calidad routinely evaluated by immunoblot on rat brain microsomal preparation
      Declaración de uso
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Información de almacenamiento y transporte
      Condiciones de almacenamiento 2 years at -20°C
      Información sobre embalaje
      Tamaño material 200 µg
      Información de transporte
      Información complementaria
      Especificaciones

      Documentation

      Certificados de análisis

      CargoNúmero de lote
      Anti-mGluR2/3 2474896
      Anti-mGluR2/3 - 16955 16955
      Anti-mGluR2/3 - 28752 28752

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Locomotor sensitization to cocaine is associated with distinct pattern of glutamate receptor trafficking to the postsynaptic density in prefrontal cortex: early versus late withdrawal effects.
      M Behnam Ghasemzadeh,Preethi Vasudevan,Christopher Mueller
      Pharmacology, biochemistry, and behavior 92 2009

      Mostrar resumen
      19135470
      Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus.
      Shigemoto, R, et al.
      J. Neurosci., 17: 7503-22 (1997) 1997

      Mostrar resumen
      9295396
      The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations.
      Petralia, R S, et al.
      Neuroscience, 71: 949-76 (1996) 1996

      Mostrar resumen
      8684625
      Ionotropic and metabotropic glutamate receptors show unique postsynaptic, presynaptic, and glial localizations in the dorsal cochlear nucleus.
      Petralia, R S, et al.
      J. Comp. Neurol., 372: 356-83 (1996) 1996

      Mostrar resumen
      8873866
      Molecular cloning, functional expression, pharmacological characterization and chromosomal localization of the human metabotropic glutamate receptor type 3.
      Emile, L, et al.
      Neuropharmacology, 35: 523-30 (1996) 1996

      Mostrar resumen
      8887960
      Immunohistochemical distribution of metabotropic glutamate receptor subtypes mGluR1b, mGluR2/3, mGluR4a and mGluR5 in human hippocampus.
      Blümcke, I, et al.
      Brain Res., 736: 217-26 (1996) 1996

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